401 zoekresultaten voor “disease prevention” in de Publieke website
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Photocleavable activity-based acid glucosylceramidase probes
Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…
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Studenten en ouderen ontwikkelen in Living Lab nieuwe aanpak eenzaamheid
Studenten van de master Vitality & Ageing bedachten in een zogenoemd ‘Living Lab' samen met ouderen een nieuwe aanpak van eenzaamheid. Bekijk hun creatieve oplossingen in vier videos voor de cursus 'The older individual', met gezondheidspsycholoog Sandra van Dijk en huisarts Wim Lely als coördinator…
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Winnie Gebhardt in het Leidsch Dagblad over vakantie
Gezondheidspsycholoog Winnie Gebhardt merkt dat de behoefte aan vakantie dit jaar groter is dan anders. Dan heeft ze het niet per se over op vakantie gaan, maar over een periode van rust en even niets moeten. Gebhardt in het Leidsch Dagblad over de veranderende coronamaatregelen: 'Die onzekerheid vinden…
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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Acute pancreatitis - from treatment to prevention
Promotie
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Preventing Future Ukraines: Conflict Prevention in Europe
Debat
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Lessons from Rare Diseases
Promotie
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
- Conference on 'Just institutional approaches to conflict prevention and resolution'
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Laat je verrassen tijdens de Healthy University workshops
Van oefeningen om gezonder te werken tot praktische tips over lekker slapen. Studenten en medewerkers die deelnemen aan de Healthy University Workshops op 18 of 19 oktober krijgen persoonlijke tips die goed bij hun situatie passen.
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Viroloog Ann Vossen bij Jinek over de uitbraak van het corona-virus
Het is een gevaarlijke virusuitbraak, maar het is nog onder controle te krijgen. Dat stelde viroloog Ann Vossen van het LUMC in tv-programma Jinek. Maar de uitspraak van de Chinese gezondheidsautoriteit dat het virus al kan worden overgedragen terwijl mensen nog geen symptomen hebben, gelooft Vossen…
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Reducing the chronic disease burden in China
Promotie
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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The synthesis of chemical tools for studying sphingolipid metabolism
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Vernieuwend Leids onderzoek ontvangt NWO-subsidie
Hoogleraar Annemarie Meijer en dr. Sander Wezenberg ontvingen op 24 januari een NWO-subsidie voor hun onderzoek. De subsidie is toegekend binnen het Open Competitie ENW-M-programma en is bedoeld voor vernieuwende onderzoeksgebieden die de basis kunnen zijn voor onderzoeksthema’s van de toekomst.
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Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT)
Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)
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The influence of leadership on the prevention of safety incidents
Promotie
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Multimodality imaging in patients with valvular heart disease and systemic diseases
Promotie
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Identification of Therapeutic Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotor: G.J.B. van Ommen
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Elucidating the pathogenesis underlying bicuspid aortic valve disease using new disease models
Promotie
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Nieuwe inzichten in mycobacteriële infecties met NWO-beurs
Waarom zijn mycobacteriën zulke succesvolle ziekteverwekkers? En zijn er verdedigingsmechanismen in het lichaam die helpen een infectie iets te verminderen? Om dit te achterhalen, heeft Annemarie Meijer de NWO Open competitie ENW-XL-beurs toegekend gekregen. Ze gaat niet alleen aan de slag. Aan het…
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Maximal Systolic Acceleration in atherosclerotic vascular disease
Promotie
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Predicting Outcomes in Patients with Kidney Disease
Promotie
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Adult weight change and cardiometabolic disease
Promotie
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Conceptualisation of disease resolution in rheumathoid arthritis
Promotie
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Cardiovascular disease burden in thoracic aortopathy
Promotie
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Inflammatory Bowel Disease in Older Patients
Promotie
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Onderzoeksgroep Governance of Crises
De onderzoeksgroep ‘Governance of Crises’ bestudeert verschijnselen, dynamiek en spelers als het gaat om crisisbeheersing. Het Crisis Research Center (CRC) van de Universiteit Leiden maakt deel uit van deze onderzoekgroep.