Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. G.R. de Snoo

Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.

Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.

Het College van Bestuur heeft besloten Dr. Antoaneta Dimitrova met ingang van 1 september 2017 te benoemen tot hoogleraar Comparative Governance binnen het Institute of Security and Global Affairs.

Simon Willmetts levert bewijs voor een systematisch beleid van directe samenspanning tussen Time Inc. en de CIA

Lezing

In de BNR Perestrojkast, een podcast over over Midden- en Oost-Europa komt Antoaneta Dimitrova, Hoogleraar Comparative Governance, aan het woord over de politieke situatie in Bulgarije.

Vraagstukken zoals klimaatverandering, uitputting van hulpbronnen of sociale ongelijkheid zijn te complex om vanuit één wetenschappelijke discipline of vanuit één land aan te pakken. De Universiteit Leiden heeft de expertise in huis om het oplossen van deze gigantische problemen een klein stapje dichterbij…

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Het onderzoeksproject begint met een kritische analyse van de effecten van vergroting van stabiliteit, democratie en welvaart van kandidaat-lidstaten aan de ene kant en de EU-instellingen aan de andere kant. De onderzoeksvraag is: Hoe kan de EU haar integratie van de capaciteit voor huidige en toekomstige…

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Description of The Regional Network on the Synergy between the Convention on Biological Diversity and the UN Convention to Combat Desertification.

Promotie

Op 14 september vond de tweede editie van de Dag van de Arbeid plaats, de carrièremiddag van de bacheloropleiding Russische Studies en de masteropleiding Russian and Eurasian Studies in Leiden. Vijftig Nederlandse en internationale studenten kwamen bijeen in het Lipsius om in gesprek te gaan met experts…

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

This project, South American population history revisited: multidisciplinary perspectives on the Upper Amazon (SAPPHIRE), investigates population dynamics in western South America on the basis of traces in the geographical, genetic, archaeological, ethnological, and linguistic record.

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Promotie

The research group Science Communication and Society aims to understand how science communication works to improve the interaction between science and society. Central themes are ‘Bridging the gap between experts and the general public’ and ‘Evaluating Science Communication’.

What invertebrates live in the fields and edges? Do the populations change with landscape complexity?

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Does a high quality prairie restoration in an urban/agricultural landscape provide invertebrates necessary for a sustainable ecosystem?

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

What invertebrates are available to feed nestlings in an agricultural landscape of varied complexity?

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Galaxies in the local Universe fall into two main categories of spirals and ellipticals. In this Thesis, we explore the structural evolution of galaxies into this bimodal distribution.

To study how planetary systems come into existence we study much younger systems still in formation.

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The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Op 28 oktober 2021 verdedigde Hein van der Bruggen zijn proefschrift en behaalde daarmee de doctorstitel.

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Promotor: S.M. Verduyn Lunel, Co-promotores: M.F.E. de Jeu, B. de Pagter

Promotor: E.F. Smets, Co-promotor: T.R. van Andel

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.