There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

In de landelijke Onderzoekschool Mediëvistiek werken onderzoekers op het gebied van de Middeleeuwen van zes Nederlandse universiteiten samen. De school verzorgt (in samenwerking met de lokale graduate schools van de universiteiten) de opleiding tot mediëvistisch onderzoeker en biedt ook opleidingsactiviteiten…

This thesis describes a study from both a theoreticaL and an experimental point of view.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

De universiteit stimuleert medewerkers hun talenten te gebruiken en te ontwikkelen.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Promotor: G.P. van Wezel

Within the field of astronomy, understanding how galaxies grow and evolve from the Big Bang to the present day is a challenging and complex question.

Promotor: T.H. Oosterkamp

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Promotor: Prof.dr. T.H.W. Bäck

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Promotor: Prof.dr. G.P. van Wezel

Promotor: P.D. Grünwald

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

Mycorrhizas are symbiotic associations between soil fungi and most plant species.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Op 13 januari 2022 verdedigde Pie Habimana het proefschrift 'Harmful Tax Competition in the East African Community'. Het promotieonderzoek is begeleid door prof.dr. H. Vording en prof.dr. S.C.W. Douma (UvA).

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

The ReCiPe methodology for Life Cycle Impact Assessment (LCIA).

Promotor: Prof.dr. H.L.V. Linnartz

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: F. Arbab

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.