Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: J.N. Kok, Co-promotor: M.S. Lew

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron (Chalmers Univ., Sweden)

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

Promotor: Prof.dr. A.G.G.M. Tielens

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

This thesis describes the design, characterization and application of dextran based crosslinked network.

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Promotor: W. T. F. den Hollander, F. H. J. Redig

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Met beschimmelde burgers, ruimtewezens en TicTacjes in de hand presenteerden studenten van het Honours College ‘Bèta & Life Science’ hoe wetenschappelijke inzichten de toekomst kunnen beïnvloeden. “Wetenschap met een algemeen publiek kunnen delen is een essentiële vaardigheid.’’

Op 15 oktober 2020 verzamelden internationale wetenschappers, vertegenwoordigers uit de praktijk en studenten zich online bij het Leiden Leadership Centre voor de conferentie ‘Leadership in Progress: Science meets practice’. Samen met gerenommeerde sprekers uit de wetenschap, politiek en de ambtelijke…

Afrika heeft een bevolking van 1,5 miljard mensen. In 2050 zal dit aantal naar verwachting stijgen tot 2,5 miljard. De impact van het continent op de wereldeconomie en samenlevingen, maar ook op het milieu, zal daardoor enorm toenemen.

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

This thesis describes how complex and real-world relevant analytical solutions can be found starting from a simple Nagumo problem posed on one or two-dimensional lattices.