This thesis describes the design, characterization and application of dextran based crosslinked network.

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Promotor: Prof.dr. J.P. Abrahams

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Promotor: Prof.dr. P.C. van Welzen

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

De masterspecialisatie Philosophical Perspectives on Politics and the Economy van de Universiteit Leiden was voorheen bekend onder de naam Philosophy, Politics and Economics.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Promotor: Prof.dr. G.P. van Wezel

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

De ontwikkeling en versterking van sociale rechten en rechten van arbeiders in Indonesië weerspiegelt de bredere processen van sociale en politieke hervormingen in het land.

De incubatietijd (van infectie tot de eerste symptomen) en latente periode (van infectie tot de start van besmettelijkheid) zijn cruciaal voor het informeren van controle maatregelen aan het begin van een infectieziektenuitbraak. Een voorbeeld is de duur van quarantaine voor potentieel geïnfecteerden,…

Hoe helpen demonstratie-experimenten in de klas leerlingen om te leren chemisch redeneren?

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

This paper describes the development process of voting behavior in Chile; particularly the relationship between the class voting theory and the theory of cultural post-materialist vote is investigated. This research deals with Chile as a case study, a developing country with a relatively stable democracy…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Kim de Jong, Jaime Delgadillo en Michael Barkham bieden waardevolle inzichten in hun boek 'Routine Outcome Monitoring and Feedback in Psychological Therapies' over hoe therapeuten en stagiaires feedback kunnen gebruiken om beslissingen over behandelingen te onderbouwen en uiteindelijk de resultaten…

Indicators to measure progress in de-linking economic growth and environmental pressure.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)

Promotor: G.R. de Snoo

Promotor: R. Gill, Co-promotor: P. Massart