The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.

The first biennial symposium Environmental History in the Medieval and Early Modern Low Countries is scheduled for October 25 and 26, 2024. This event aims to facilitate the exchange of recent research, ongoing projects, and key discussions within the realm of environmental history among scholars from…

De Jan Brouwer scriptieprijs voor Maatschappijwetenschappen 2015 is op 14 april uitgereikt aan oud Masterstudent Public Administration Raffael Hanschmann voor zijn scriptie “The impact of the economic crisis on EU environmental policy making. Insights from discourse network analysis”.

Bij LUC The Hague stel je je eigen curriculum samen rond de afstudeerrichting van jouw keuze: je major. Een centraal thema in de studie is Global Challenges; in iedere major houd je je bezig met uitdagingen in de echte wereld, en je leert hoe je deze beter kunt begrijpen.

Promotores: R. Tijdeman, K.J. Batenburg

This study’s main aim is to test whether children’s learning behaviour explains why they do not benefit from a literate environment.

Op woensdag 30 november 2016 promoveert Florentin Blanc op zijn proefschrift 'From Chasing Violations to Managing Risks Origins'. De verdediging vindt plaats om 11.15 uur in het Academiegebouw van Universiteit Leiden. De promotor is professor Wim Voermans.

In this thesis, several aspects of software debugging from automated crash reproduction to bug report analysis and use of contracts have been studied.

The LUGO Press is a student publication forum, rooted in academia and journalistic practices and published by the Leiden University Green Office.

Around the world, mindfulness has become big business. This course combines conventional scholarly inquiry from multiple disciplines with experiential learning to provide a responsible, comprehensive, and inclusive education about mindfulness as a contemporary phenomenon.

Deze opleiding biedt de mogelijkheid om onderzoek op moleculair, cellulair en organismaal niveau te verenigen, maar biedt ook de mogelijkheid om je te specialiseren op één van deze niveaus.

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Promotor: Prof.dr. H.S. Overkleeft

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Indicators to measure progress in de-linking economic growth and environmental pressure.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk

Creating information portals for support of European environmental policy.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Promotores: H.W. Lenstra, A. Lucchini

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Exploring linkages between energy and material use and implications for sustainable development.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Voor het eerst is een bedrijf door een rechter gedwongen CO2-uitstoot te verlagen. Het is een volgens juristen baanbrekende uitspraak die gevolgen heeft voor Shell en mogelijk ook soortgelijke bedrijven.

Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)

From Incident to Precedent

Dit artikel beschrijft een overzicht van twee decennia na 9/11 in West-Europa. De auteurs kijken naar de ontwikkeling van de dreiging, het contra-terrorismebeleid en de impact hiervan op de samenleving.

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