The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.

While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

In unconventional high temperature superconductors, supercurrent vortices are known to spoil the Landau levels. In this thesis the emergence of Landau levels is studied in different types of superconductors: Weyl superconductors, and the Fu-Kane heterostructure.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Ruim 160 jaar geleden was het de Haagse fotopionier en reiziger Alexine Tinne (1835-1869) die het huidige Zuid-Soedan en haar bewoners vastlegde op de gevoelige plaat. Ze behoren tot de aller vroegste foto’s die in het hart van het Afrikaanse continent werden gemaakt.

De special 'Missie Geslaagd?' van het geschiedenis televisieprogramma Andere Tijden gaat over de laatste paters van de Congregatie van de Heilige Geest in Gennep. Hoogleraar Culturele Antropologie en Sociologie van Afrika Peter Pels is een van de specialisten van deze uitzending. Hij vertelt over de…

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Op 21 maart 2019 verdedigde James Welch zijn proefschrift 'The Grotius Sanction: Deus Ex Machina. The legal, ethical, and strategic use of drones in transnational armed conflict and counterterrorism'. Het promotieonderzoek is begeleid door promotor prof. dr. P.B Cliteur.

Kunst en vrije tijd, Kunst en vrije tijd

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Buurlanden van Mali bespraken eergisteren de staatsgreep in het Afrikaanse land van een maand geleden. Wat was het doel van de coupplegers? En in hoeverre is het land opgeschud door deze nieuwe situatie? Dat vertelt de Mirjam de Bruijn, hoogleraar Afrikanistiek, in een podcast van NU.nl.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

The transition to electric vehicles (EVs) reduces vehicle emissions to combat climate change. EVs raise concerns regarding the production of lithium-ion batteries and related emissions; while batteries can also provide energy storage services for the electricity system.

Promotor: V. Vitelli, Co-promotor: J. Paulose

Het Nederlands Instituut Marokko, Nimar, krijgt een nieuwe, bredere opdracht waarbij verdieping van de kennis van elkaars samenleving, cultuur en taal centraal staat. De Universiteit Leiden wordt verantwoordelijk voor het onderzoek en onderwijs van het Nimar.

In this thesis, we study travelling waves in stochastic reaction-diffusion equations. We extend techniques from the deterministic theory for travelling waves to apply to the stochastic version, which allows us to compute the stochastic wave speed and shape, and draw conclusions on the stability of the…

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

Op 1 juni 2022 verdedigde Tom Herrenberg het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. P.B. Cliteur en prof.dr. B.R. Rijpkema.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Oplossingen bedenken voor mondiale vraagstukken zoals milieuvervuiling en armoede. Dat doen jongeren die vanuit de hele wereld samenkomen op de top One Young World van 17 tot en met 20 oktober in Den Haag. Volg de Leidse studenten Jennifer Pfister en Thomas Gevers die verslag doen van hun ervaringen…

Promotores: J. Jonkers, K.E. de Visser

Who are open-source intelligence activists and how reliable are their contributions to public understanding of Russia’s war in Ukraine?