The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Het twaalver-sjiisme speelde een centrale rol in de these en antithese waaruit de islam ontstond, en is vandaag de dag nog steeds zeer invloedrijk. Het doel van project ImBod is om de eerste complete sociale geschiedenis van het imamaat te schrijven.

Diplomatiek onderhandelen is een moeilijk te begrijpen en te beheersen proces. Toch is het onderhandelen tussen staten en in internationale organisaties van levensbelang voor het functioneren van het internationale bestel.

Creating information portals for support of European environmental policy.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

BSc-programma’s: ‘Political Science’, ‘International Relations and Organisations’. MSc-opleiding: Political Science, met specialisaties ‘International Organisation’; ‘Dutch Politics; ‘Nationalism, Ethnic Conflict, and Development’; ‘International Politics’; ‘Political Legitimacy and Justice’; ‘Democracy…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Het Brain and Education lab is een onderzoeksgroep van het Instituut Pedagogische Wetenschappen aan de Universiteit Leiden en maakt deel uit van het Leiden Institute for Brain and Cognition (LIBC). Ons onderzoek richt zich op de ontwikkeling van cognitieve processen die betrokken zijn bij leren en academische…

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Promotor: A.P. IJzerman

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Op 9 januari 2019 verdedigde Marieke Wierda haar proefschrift 'The Local Impact of a Global Court: Assessing the Impact of the International Criminal Court in Situation Countries'. Het promotieonderzoek is begeleid door promotoren prof. dr. C. Stahn en prof.dr. L.J. van den Herik.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Deze uitgave is het eerste integrale overzichtswerk op het gebied van fraude en fraudebestrijding waarin wetenschappers én praktijkmensen de belangrijkste aspecten van fraude, fraudepreventie en fraudebestrijding analyseren. Erwin Muller en Pinar Ölcer, beiden werkzaam bij het Instituut voor Strafrecht…

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

Promotor: A.P. IJzerman

De programmagroep Neuropedagogiek en ontwikkelingsstoornissen richt zich op bestudering van ontwikkeling van kinderen en adolescenten, met de nadruk op de ontwikkeling van probleemgedrag.

Promotores: J. Kok, M. Chaudron (Chalmers University)

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Alles met betrekking tot politiek, bestuur en communicatie valt samen in dit domein. Als cursist voor de bekende Public Affairs basis- en verdiepingsleergang wordt de verbinding tussen de politieke en maatschappelijke omgeving gelegd en krijg je inzicht in politieke en bestuurlijke processen. Daarnaast…

De onderliggende gedachte van de Masteropleiding is dat je (1) begint met een concrete uitdaging, (2) dan vanuit wetenschappelijke perspectieven reflecteert op de uitdaging, (3) om vervolgens de academische kennis weer toe te passen op (zelfgekozen) maatschappelijke, economische en bestuurlijke vra…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

Which traits and/or trade-offs determine benefits of being deciduous or evergreen?

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

De minor Creative Strategies for a Society in Change (CSSC) legt een verbinding tussen het verkrijgen van inzicht in creatieve maakprocessen en het verkennen van maatschappelijke problematieken die kenmerkend zijn voor onze tijd.

Als natuurkundige onderscheid je je met een stevige wiskunde- en programmeerachtergrond en een sterk analytisch en probleemoplossend vermogen.

Het doel van dit project is om een duidelijk overzicht te krijgen van duurzaamheidsinspanningen die binnen de faculteiten worden gedaan, evenals het leggen van blijvende verbindingen tussen universiteitsmedewerkers en studenten die bij deze inspanningen betrokken zijn. Het Leiden University Green Office…

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

Wij bestuderen de dagelijkse praktijk van individuen, groepen en gemeenschappen - zowel in Nederland als wereldwijd - om ze te plaatsen binnen de complexe processen van sociale en globale ontwikkeling. In Leiden zijn we gespecialiseerd in de gevolgen van globalisering op het gebied van milieu, sociale…

This project investigates the rich linguistic history of the crucial language groups in East Africa and includes a search for words that indicate earlier lost languages. These outcomes, combined with recent archaeological and genetic research, will contribute to a new understanding of East Africa’s…

Due to the almost complete disappearance of the archive of the Old Dutch West India Company (WIC, 1621-1674) not much is known about the ships and crews of this company. In this project we start the reconstruction of this basic information making use of new digital humanities techniques to extract this…

Forgotten Lineages explores the paths through which generations of formally enslaved and their descendants gradually forgot their past of enslavement under Dutch and British imperial rule and became local subjects in Sri Lanka and South Africa. It explores why and how forgetting rather than memory became…