Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Promotor: Prof.dr. R.M.H. Merks

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Studievoorlichting

Studievoorlichting

Geesteswetenschappen, Centre for the Arts in Society

Join-in courses zijn MA-cursussen over middeleeuwse onderwerpen gegeven binnen vastgestelde MA-programma's van de zes deelnemende universiteiten van de Onderzoekschool. Op aanvraag zijn deze vakken toegankelijk voor studenten van andere (Nederlandse) universiteiten. De cursusbelasting en het aantal…

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Vorige week zondag werd oppositieleider Juan Guaidó door president Maduro met geweld uit het parlement geweerd. Guaidó zou daar door een oppositiemeerderheid worden herkozen tot voorzitter. Het is de vraag of de Venezolanen er zelf nog in geloven, aldus Patricio Silva, hoogleraar Latijns-Amerikaanse…

Hieronder vind je de antwoorden op een aantal veelgestelde vragen over toelating tot de klinische specialisaties van de Master Psychologie.

Het Instituut voor Geschiedenis feliciteert Mirjam de Bruijn met het verkrijgen van een VICI-subsidie voor het onderzoek 'Connecting in Times of Duress: Understanding Communication and Conflict in Middle Africa’s Mobile Margins.'

Is wetenschappelijk onderzoek wel nuttig? Jorrit Smit beargumenteert dat voor een antwoord op deze vraag niet gekeken moet worden naar bijvoorbeeld vooraanstaande wetenschappers of invloedrijke organisaties, maar naar de plekken waar kennisuitwisseling en co-creatie plaatsvinden. Promotie 6 mei.

Met de publicatie “Think tanks and strategic policy-making: the contribution of think tanks to policy advisory systems” heeft Bert Fraussen, als universitair docent verbonden aan het Instituut Bestuurskunde, de Harold D. Lasswell Prize gewonnen.

Leids rechtshistorisch onderwijs

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

Faciliteiten waar LIBC leden gebruik van kunnen maken (in het Engels):

Hifadhi ya Dijiti ya Ustadh Mau

Hieronder kun je een antwoord vinden op de meestgestelde vragen over de master. Wordt jouw vraag niet beantwoord? Neem gerust contact met ons op voor een gepersonaliseerd antwoord via: masterhas@lumc.nl.

Gianclaudio Malgieri zal, samen met Professor Alessandro Mantelero van de Polytechnic University of Turijnde, de

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Dr. Helen Pluut heeft een artikel gepubliceerd in het gerenommeerde tijdschrift Organizational Behavior and Human Decision Processes (OBHDP). Dit in samenwerking met Remus Ilies (National University of Singapore), Petru Curşeu (Open Universiteit en Babeş-Bolyai University) en Yukun Liu (University of…

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

Op 18 september 2019 verdedigde Huw Llewellyn zijn proefschrift 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.M. Blokker en prof.dr. L.J. van den Herik.

The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

A single self-assembled semiconductor quantum dot in a high-finesse optical microcavity - the subject of this thesis - is an interesting quantum-mechanical system for future quantum applications. For instance, this system allows trapping of an extra electron and thus can serve as a spin quantum memory,…

What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

Promotor: Richard D. Gill

BioSolar Cells is a five-year research project in which ten knowledge institutions and 45 private industries work together.

Does the presence of Ring-necked parakeets negatively influence feeding and feeding behaviour of native bird species on artificial bird feeders and if so, what are possible solutions?

CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.

Some examples of research questions include: What framework of circular strategies should local practitioners use? How should practitioners organize their monitoring of the circular economy activities in the region of interest? What are the main products that have the most circular potential in the…