This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

In this thesis, we present new laboratory data of interstellar dust analogues.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

Promotor: A.P. IJzerman

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Comparing the global warming potential (GWP) of the service provided by an iRex Digital Reader to the same service provided by an office printer using a scanning LCA.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Promotor: F.S. de Boer, Co-promotor: M.M. Bonsangue

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Promotor: A.P. IJzerman

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn