Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

The project

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Ontdek deze cursus introductie tot coaching van het ICLON en leer docenten in opleiding effectief te ondersteunen in hun professionele ontwikkeling. Lees hier meer!

Talk + Gaming Workshop

Met intens verdriet heeft de Faculteit der Rechtsgeleerdheid kennisgenomen van het plotselinge overlijden van professor Aart Hendriks op 9 februari 2025.

This research project studies the distribution and impact of medieval malaria in the Netherlands.

Waar ontleen jij je gevoel van eigenwaarde aan? Niet een vraag die je snel zou verwachten bij een vak over leiderschap. Docent Michel Don Michaloliákos koos voor een unieke invulling van A Taste of Leadership, een Honours-vak met introspectie als kernthema.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

Cursus

‘We must be in the Netherlands, because it isn’t even three o’clock yet and we have already started!’, lacht Pamela Hack, de Amerikaanse Deputy Consul General. Afgelopen week bezochten de scholieren van de Pre-Class ‘Political American History’ de nieuwe Amerikaanse ambassade in Wassenaar. Wat volgde…

The Grotius Centre, in collaboration with Duke Law School, will be hosting the Duke-Leiden Institute in Global and Transnational Law from 16 June to 17 July 2019 in The Hague, the International City of Peace and Justice. Applications for the second edition are now open!

This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

It researches (the possibilities for) the development of a set of principles and best practices for insolvency office holders by comparing multilateral treaties and soft law recommendations and national legislation within Europe.

CML-IA is a database that contains characterisation factors for life cycle impact assessment (LCIA) and is easily read by the CMLCA software program.

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

Heart failure is a major health care problem with high mortality.

Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?

Promotor: S.M. Verduyn Lunel

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law.

Promotor: Prof.dr. M. Ubbink

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Op 11 november 2021 verdedigde Evelien Campfens het proefschrift 'Cross-border Claims to Cultural Objects'. Het promotieonderzoek is begeleid door prof.dr. N.J. Schrijver en prof.dr. W.J. Veraart (VU Amsterdam).

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Aan de opleidingen van het Centre for Professional Learning op het gebied van Terrorisme, Recht en Veiligheid zijn verschillende (research) fellows verbonden. De fellows geven advies over de inhoud van het curriculum en de verbinding tussen wetenschap en praktijk.

Archeologen van het onderzoeksproject ’Innovating Objects’ proberen te achterhalen hoe voorwerpen uit andere culturen de Romeinse samenleving veranderden en de identiteit van de Romeinen beïnvloedden.

Miguel John Versluys zat in de adviescommissie voor de Ammodo Science Award for groundbreaking research 2022. Ammodo interviewde hem over onder meer zijn onderzoek naar de culturele diversiteit van het Romeinse Rijk waarin hij inzichten en methoden uit de sociale, geestes- en natuurwetenschappen com…

De YAL laat zich horen over beleidskwesties.

Lezing