Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: Prof.dr. J.W.M. Frenken

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

Development of GHG calculator for bio-electricity and heat.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

This project investigates the rich linguistic history of the crucial language groups in East Africa and includes a search for words that indicate earlier lost languages. These outcomes, combined with recent archaeological and genetic research, will contribute to a new understanding of East Africa’s…

The project Multimedia Research and Documentation of African Oral Genres: Connecting Diasporas and Local Audiences (Director: D.Merolla) focuses on multimedia as technology that allows scholars to share documentation and scientific knowledge with the cultural owners of the collected oral genres.

A warm welcome to the students of the Master’s Programme in European Law 2018-2019. This year, we expect around 60 students who will start this LL.M. programme, organised by the Europa Institute. Our faculty staff is excited to meet you and to teach you all aspects of European Law.

Drie docenten van Geesteswetenschappen ontvingen dit jaar de Senior Kwalificatie Onderwijs (SKO). Universitair docent Bruno Verbeek is een van hen. Wat maakt onderwijs volgens hem goed?

‘Ontzettend blij’ was Markus Altena Davidsen toen hij hoorde dat hij en zijn collega’s een subsidie hadden ontvangen van het KNAW-Pilotfonds Wetenschapscommunicatie. Samen met partners uit het hele land werken ze aan een boek dat middelbare scholen moet inspireren hun onderwijs over religie en levensbeschouwing…

Oratie

Co-creatie en multidisciplinair leren over grenzen heen.

Joni Reef is universitair docent criminologie en research fellow bij de afdeling Criminologie aan de Universiteit van Leiden.

Astrid van Weyenberg wil studenten wetenschapscommunicatie en nieuwe vormen van mediawijsheid als academische vaardigheden bijbrengen.

Victor Gijsbers gaat activerende technieken ontwikkelen voor de cursus Wetenschapsfilosofie voor geesteswetenschappen.

Bart Barendregt ontwikkelt een multimodale, methodologische toolkit.

Victor Gijsbers gaat activerende technieken ontwikkelen voor de cursus Wetenschapsfilosofie voor geesteswetenschappen.

Online scriptiebegeleiding

Bart Barendregt ontwikkelt een multimodale, methodologische toolkit.

Ontwikkeling van een seminar die studenten leert hoe ze boeiende verhalen over het verleden kunnen vertellen.

Wat veroorzaakt leerproblemen bij pleegkinderen

Hoe stimuleer je dat de nieuwe uitgangspunten van het curriculum Geneeskunde verder vorm krijgen in het onderwijs?

Spotten van ondernemend talent & het betrekken van alumni.

Studenten leren hoe ze duidelijk medicijnadvies aan patiënten kunnen geven.

Verbeteren mentoraatprogramma voor eerstegeneratiestudenten

Lezing

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

Van zwarte gaten tot kunstmatige intelligentie en van medicijnonderzoek tot data science: welkom in de fascinerende wereld van de Faculteit der Wiskunde en Natuurwetenschappen. Geregeld geven onze onderzoekers, studenten en gasten publieke lezingen over hun werk. U bent van harte uitgenodigd.

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

The Minor in Business Administration teaches business knowledge and skills that are important for your future career.

Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.