2,829 zoekresultaten voor “specifieke for a” in de Publieke website
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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Painting with starlight : optical techniques for the high-contrast imaging of exoplanets
This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.
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Self-Adjusting Surrogate-Assisted Optimization Techniques for Expensive Constrained Black Box ProblemsBagheri, S.
Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.
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data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
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Mining the kinematics of discs to hunt for planets in formation
Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Artificial metallo-proteins for photocatalytic water splitting: stability and activity in artificial photosynthesis
Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.
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Nanofluidic tools for bioanalysis : the large advantages of the nano-scale
Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)
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Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace
Op 10 juni 2021 verdedigde Merinda Stewart haar proefschrift 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. J.J. Rijpma.
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The electrode-electrolyte interface in CO2 reduction and H2 evolution: a multiscale approach
Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.
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A New Model of Global Governance in International Tax Law Making (GLOBTAXGOV)
Dr. Irma Mosquera Valderrama onderzoekt in haar ERC-project de rol van de OESO (Organisatie voor Economische Samenwerking en Ontwikkeling) en de EU bij de totstandkoming van internationale fiscale wetgeving en streeft ernaar voorwaarden te scheppen waaronder zowel ontwikkelde landen als ontwikkelingslanden…
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Managing a sustainable career in the contemporary world of work: Personal choices and contextual challenges
Op 9 juni 2020 verdedigde Maral Darouei haar proefschrift 'Managing a sustainable career in the contemporary world of work: Personal choices and contextual challenges'. Het promotieonderzoek is begeleid door promotor prof.dr. J.I. van der Rest.
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Unveiling the third dimension: vertical structure as a probe of planet formation conditions
Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Life Cycle Assessment-Based Guidance for development of New Energy Technologies
The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.
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An Update and Expansion of a Meta-Analysis on Shared Book Reading
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Online Course Anatomy of the Abdomen and the Pelvis: a journey from basic to clinic
In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.
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BRCA1-associated breast cancer: finding new weapons for an old villain
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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Challenges of New Media for the Development of Early Literacy Skills in Children at Risk
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On the efficacy of digitized storybooks for young learners with attention problems
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Teachers' use of progress data in planning and evaluating instruction for students with learning disabilities
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Computer interventions for young children at risk to prevent reading impairments
This study’s main aim is to test whether children’s learning behaviour explains why they do not benefit from a literate environment.
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Instrumentos musicais nas línguas bantu e a herança no português do Brasil
Op 25 september promoveert Alzenir Mendes Martins de Menezes. Het Leiden University Centre for Linguistics feliciteert Alzenir!
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Protecting Places of Worship in Europe: a Review of Literature and Future Research Trends
In deze publicatie onderzochten May Tamimova en Tahir Abbas de bestaande literatuur over geweld en haat tegen gebedshuizen.
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A Sociolinguistic Study of an Ewe-based Youth Language of Aflao, Ghana
Op 26 september promoveert Cosmas Rai Amenorvi. Het Leiden University Centre for Linguistics feliciteert Cosmas!
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Risk perception and interpersonal discussion on risk: A systematic literature review
Dit artikel wil een coherente basis bieden voor empirische studies naar interpersoonlijke discussies over risico's.
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and issue prioritisation by political and managerial decision-makers: A discrete choice experiment
In dit artikel wordt het concept van probleemprioritering binnen de context van bestuurskundig onderzoek verkend.
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Towards photo-CIDNP MAS NMR as a generally applicable enhancement method
Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)
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Regulating a Revolution: Small Satellites and the Law of Outer Space
Op 18 juni 2019 verdedigde Neta Palkovitz Menashy haar proefschrift 'Regulating a Revolution: Small Satellites and the Law of Outer Space'. Het promotieonderzoek is begeleid door promotoren prof. dr. P.M.J. Mendes de Leon en prof. dr. G. Molier.
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Photoinduced processes in dye-sensitized photoanodes under the spotlight: a multiscale in silico investigation
With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
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SAFE and SOUND: Towards Evidence-based Policies for Safe and Sound Robots
SAFEandSOUND heeft de ambitie om de beleidscyclus te verbinden met gegevens die zijn gegenereerd in robottestzones om empirisch onderbouwde beleidsvorming voor robottechnologieën te ondersteunen.
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Delegation to Treaty Bodies and International Organisations for Conventional Arms Control Agreements in Europe
In dit artikel onderzoekt William Lippert hoe het overdragen van taken aan een uitvoerder van een overeenkomst van conventionele wapenbeheersing in Europa van invloed is op het succes ervan.
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Shaping multilateralism: Principles and opportunities for multilateral cooperation in the UN
Hoe kan internationale samenwerking worden bevorderd, nu de steun voor de mulilaterale aanpak van problemen afkalft? Gisela Hirschmann (Universiteit Leiden) en Cornelia Ulbert (Universiteit van Duisburg-Essen) doen enkele aanbevelingen.
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Mentale impact ‘COVID’ verschilde sterk per soort klachten en specifieke groep
Mensen die al voor de COVID-pandemie gediagnosticeerd waren met een psychische stoornis vertoonden geen sterkere toename van symptomen dan anderen. Dit is één van de uitkomsten van het eerste systematische overzicht van studies naar de psychische impact van COVID die hun onderzoekspopulatie ook voor…
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Universiteit Leiden stuurt delegatie naar interuniversitaire workshop ‘A Future for EU’ (F4EU)
Van 27 februari tot 1 maart 2018 namen studenten uit vier verschillende universiteiten deel aan de interuniversitaire workshop “A future for EU” (F4EU) in het Belgische Luik.
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and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Universal adelic groups for imaginary quadratic number fields and elliptic curves
Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)
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Are we there yet? Advances in anytime-valid methods for hypothesis testing and prediction
Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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T-CYCLE EPR: Development at 275 GHz for the study of reaction kinetics & intermediates
A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.
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Supercritical carbon dioxide spray drying for the production of stable dried protein formulations
Promotor: W. Jiskoot, Co-promotor: H.A. Every