A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Remus Dame

Op 10 oktober 2019 verdedigde Laure d'Hondt haar proefschrift 'Addressing Industrial Pollution in Indonesia. The Nexus between Regulation and Redress seeking'. Het promotieonderzoek is begeleid door promotor prof.dr. A.W. Bedner.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Op 7 februari 2019 verdedigde Helena Ursic-Vrabec haar proefschrift 'Uncontrollable: Data subject rights and the data- driven economy'. Het promotieonderzoek is begeleid door promotor prof. dr. S. van der Hof.

Promotor: Prof.dr. G.J. Kroes

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Het twaalver-sjiisme speelde een centrale rol in de these en antithese waaruit de islam ontstond, en is vandaag de dag nog steeds zeer invloedrijk. Het doel van project ImBod is om de eerste complete sociale geschiedenis van het imamaat te schrijven.

Diplomatiek onderhandelen is een moeilijk te begrijpen en te beheersen proces. Toch is het onderhandelen tussen staten en in internationale organisaties van levensbelang voor het functioneren van het internationale bestel.

Creating information portals for support of European environmental policy.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

BSc-programma’s: ‘Political Science’, ‘International Relations and Organisations’. MSc-opleiding: Political Science, met specialisaties ‘International Organisation’; ‘Dutch Politics; ‘Nationalism, Ethnic Conflict, and Development’; ‘International Politics’; ‘Political Legitimacy and Justice’; ‘Democracy…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Het Brain and Education lab is een onderzoeksgroep van het Instituut Pedagogische Wetenschappen aan de Universiteit Leiden en maakt deel uit van het Leiden Institute for Brain and Cognition (LIBC). Ons onderzoek richt zich op de ontwikkeling van cognitieve processen die betrokken zijn bij leren en academische…

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Promotor: A.P. IJzerman

The aim of this project was to estimate emissions from lead products-in-use for the past, the present and the future and assess the development of toxicological risks associated with these products.

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Op 9 januari 2019 verdedigde Marieke Wierda haar proefschrift 'The Local Impact of a Global Court: Assessing the Impact of the International Criminal Court in Situation Countries'. Het promotieonderzoek is begeleid door promotoren prof. dr. C. Stahn en prof.dr. L.J. van den Herik.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Deze uitgave is het eerste integrale overzichtswerk op het gebied van fraude en fraudebestrijding waarin wetenschappers én praktijkmensen de belangrijkste aspecten van fraude, fraudepreventie en fraudebestrijding analyseren. Erwin Muller en Pinar Ölcer, beiden werkzaam bij het Instituut voor Strafrecht…

This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.

Promotor: A.P. IJzerman

De programmagroep Neuropedagogiek en ontwikkelingsstoornissen richt zich op bestudering van ontwikkeling van kinderen en adolescenten, met de nadruk op de ontwikkeling van probleemgedrag.

Promotores: J. Kok, M. Chaudron (Chalmers University)

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Alles met betrekking tot politiek, bestuur en communicatie valt samen in dit domein. Als cursist voor de bekende Public Affairs basis- en verdiepingsleergang wordt de verbinding tussen de politieke en maatschappelijke omgeving gelegd en krijg je inzicht in politieke en bestuurlijke processen. Daarnaast…

De onderliggende gedachte van de Masteropleiding is dat je (1) begint met een concrete uitdaging, (2) dan vanuit wetenschappelijke perspectieven reflecteert op de uitdaging, (3) om vervolgens de academische kennis weer toe te passen op (zelfgekozen) maatschappelijke, economische en bestuurlijke vra…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.