Human vocal communication and music perception represent advanced cognitive skills, seemingly innate and universal. These faculties encompass a range of perceptual and cognitive abilities. Cross-species research sheds light on the origins of musicality by investigating whether these traits are shared…

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

Verreweg de meeste studenten kiezen voor de masteropleiding Astronomy. Je kunt ook doorstromen naar de masteropleiding Physics of kiezen voor een masteropleiding aan een buitenlandse universiteit.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Cursus, Leergang

Cursus, Leergang

Doordat experience based learning een belangrijk onderdeel is van onze opleiding, kom je tijdens de studie veel in aanraking met de praktijk. Zo krijg je vaak onderwijs van docenten die ook praktiserend apotheker zijn, onderzoek doen of werkzaam zijn op beleidsmatig vlak. Ook loop je coschappen en…

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

Het project onderzoekt de impact van de botsing tussen voorstanders van regelsgebaseerde orde en internationaal recht op mondiaal bestuur en rechtssystemen.

De apotheker van de toekomst is naast een geneesmiddelenexpert ook mede-behandelaar. Er is een steeds grotere behoefte aan apothekers die kennis hebben van farmaceutische producten én de patiëntenzorg. De masteropleiding Farmacie aan de Universiteit Leiden wil apothekers opleiden die de rol vervullen…

De apotheker van de toekomst is naast een geneesmiddelenexpert ook mede-behandelaar. Er is een steeds grotere behoefte aan apothekers die kennis hebben van farmaceutische producten én de patiëntenzorg. De masteropleiding Farmacie aan de Universiteit Leiden wil apothekers opleiden die de rol vervullen…

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Promotie

Promotie

Promotie

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In this thesis,

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.

De programmagroep Opvoeding en Ontwikkeling is verantwoordelijk voor onderwijs op zowel bachelor- als masterniveau, met speciale aandacht voor opvoeding en ontwikkeling.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.