Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

-

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Promotie

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Promotie

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Als een nieuwe methode is ontwikkeld om een (neuro-)psychologische aandoening of hieraan gerelateerde gedragsfactoren te herkennen en te behandelen, kan deze nog niet direct in de klinische praktijk worden ingezet. Eerst moet de methode geëvalueerd worden, bij voorkeur in gerandomiseerde, gecontroleerde…

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

Promotie

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

De effecten van veel behandelingen worden in belangrijke mate bepaald door andere factoren dan het geneesmiddel of de behandeling zelf. Zo kunnen placebo-effecten even groot zijn als het effect van bijvoorbeeld antidepressiva of pijnstillers. Factoren die hieraan bijdragen zijn het vertrouwen in de…

Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)

Aangezien jeuk en pijn zeer belastend kunnen zijn, vooral wanneer mensen chronisch aan (een van) deze symptomen lijden, is het belangrijk te weten door welke factoren deze gewaarwordingen worden beïnvloed. Het wordt steeds duidelijker dat psychologische factoren een belangrijke rol spelen bij het ervaren…

Promotie

M. Danhof, Co-promotores: J. Freijer, A. Yassen

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Promotor: S.M. Verduyn Lunel

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Begrijpen van het evoluerende landschap van extremisme in de 21e eeuw.

Europese burgers worden geconfronteerd met uitdagingen op het gebied van globalisering, migratie, technologische ontwikkelingen en klimaatverandering. Deze uitdagingen vergen het uiterste van onderlinge internationale en intergenerationele solidariteit, wat rechtstreeks betrekking heeft op de grondslagen…

De eerste index om de veiligheid, duurzaamheid en circulariteit van producten te meten, waarmee ze het EU-kader (SSbD) operationaliseren.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Promotie

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Hoe worden nachtruimtes verbeeld, geproduceerd, ervaren en verteld door migrantengemeenschappen in Europa? Dit onderzoeksproject onderzoekt deze vraag in acht Europese steden: Aarhus, Amsterdam, Berlijn, Cork, Galway, Lissabon, Londen en Rotterdam.