Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

Promotor: T.J. Aartsma, Co-promotor: R.N. Frese

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Jessica Vance Roitman en Wouter Veenendaal, onderzoekers aan het Koninklijk Instituut voor Taal-, Land- en Volkenkunde (KITLV)/Royal Netherlands Institute of Southeast Asian and Caribbean Studies, onderzoeken de oorsprong, ontwikkeling en consolidatie van politieke oligrachie op St. Maarten. Doorgaans…

The first direct detection of gravitational waves opened the possibility of mapping the Universe via this new and independent messenger.

Description of 20th century changes in the Dutch flora: Description and interpretation (1999 - 2005)

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

PUMA aims at composing a geological map of the urban mine of Amsterdam for a selection of metals. Where are main deposits of copper, iron and aluminium located, when will they become available for secondary production, in what state and shape are they?

The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

An algorithm is discussed to compute the exponential representation of principal units in a finite extension field F of the p-adic rationals.

Promotor: Prof.dr. M.L. van Heck, Co-Promotor: B.P. Tighe

In dit artikel gaan Joris Larik en Richard Ponzio in op het belang van de Summit of the Future om multilaterale samenwerking een nieuw leven in te blazen en te versterken in een tijdperk van toenemende concurrentie tussen de grootmachten.

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

An account of the total of material flows going in, out and through Amsterdam.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L.B.F.M. Waters (UvA), Prof.dr. C. Dominik (UvA)

We have conducted a full spectral line survey of the 3-13 micron region of two massive protostars, AFGL 2591 and AFGL 2136, for the first time at high spectral resolution.

In this dissertation several settings in the Online Learning framework are studied. The first chapter serves as an introduction to the relevant settings in Online Learning and in the subsequent chapters new results and insights are given for both full-information and bandit information settings.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

My work focuses on a class of astronomical objects called protoplanetary disks.

In this course, you will learn about sustainability and staying with the environmental boundaries of our planet. You will gain an understanding of the effects of growing affluence and population growth, the key challenges we are facing, and ways to influence your direct environment.

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

Op 11 februari 2020 verdedigde Clara van Dam haar proefschrift 'Guidance documents of the European Commission in the Dutch legal order'. Het promotieonderzoek is begeleid door promotoren prof.dr. W. den Ouden en prof.dr. J.E. van den Brink (UvA).

Op 24 juni 2021 verdedigde Jing Zhang zijn proefschrift 'The Rationale of Publicity in the Law of Corporeal Movables and Claims'. Het promotieonderzoek is begeleid door promotoren prof.dr. H.J. Snijders en dr. J.A. van der Weide.

De coronacrisis vraagt om een grensoverschrijdende aanpak en samenwerking tussen landen. De Europese Unie, echter, speelde tot dusverre geen sleutelrol. Politicoloog Amy Verdun (Universiteit Leiden) legt uit waarom.

Dit project beoogt de multidirectionele effecten van gedwongen en vrijwillige vormen van migratie in het oude Nabije Oosten te onderzoeken.

Dit artikel onderzoekt hoe ISIS en de Taliban steun hebben gekregen door hun parallelle rechtssystemen.

Op 20 juni promoveert Camil Staps. Het Leiden University Centre for Linguistics feliciteert Camil!

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.