Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

The use of increasingly large and diverse datasets to guide urban climate action has implications for how, and by whom, local governments are held accountable.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'

Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.

Op 7 februari 2019 verdedigde Helena Ursic-Vrabec haar proefschrift 'Uncontrollable: Data subject rights and the data- driven economy'. Het promotieonderzoek is begeleid door promotor prof. dr. S. van der Hof.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Kieltyka

The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Machine Learning is becoming a more and more substantial technology for industry.

Een vergelijkende analyse van legitimeringsstrategieën in drie landen: Rusland, Venezuela en de Seychellen.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Indigenous Latin American artifacts have attracted the interest of Europeans since the earliest moment of contact between Europeans and the Indigenous peoples of the Americas. The ERC-funded BECACO project uses an innovative multidisciplinary framework to investigate the provenance of ethnographic and…

In deze studie staat de beheersing van seks en jongeren middels de reactie van met name strafrechtelijke autoriteiten centraal.

Promotor: Prof.dr. B.R. Katzy

Promotor: H.J.M. de Groot

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

From 16 to 19 September 2021 a hybrid conference will take place on animation in the Middle Ages. This conference is a cooperation between the University of Bergen (Norway) and the A. Zelwerowicz National Academy of Dramatic Art in Warsaw, Branch Campus in Bialystok (Poland).

Promotie

Triplet superconductivity refers to a condensate of equal-spin Cooper pairs (pairs of electrons with equal spin).

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Prof.dr. J. Memelink

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Has the industrial sector in China effectively been decarbonizing in recent years, across different regions and subsectors, and is it plausible that it will reduce its CO2 emissions in conformity with national and internationally pledged emission goals?

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros