The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Cardiovascular syndromes are the major cause of death in Western societies.

How the global distribution of vegetation stands dominated by arbuscular and ectomycorrhizal plants relate to principle aspects of belowground carbon accumulation processes?

Promotor: B. van de Water

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In this work, we attempt to answer the question:

Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.

Herkennen huisartsen kinderen die (een verhoogd risico voor) angststoornissen hebben en is er een patroon dat kan helpen om kinderen met en zonder angststoornissen te onderscheiden in de huisartsenpraktijk?

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Promotor: Prof.dr. B. van de Water

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

LIBC PUBLIEKSDAG 'HUMAN POTENTIAL; OPTIMALISEER JEZELF, TRAIN JE HERSENEN' (in Dutch)

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Promotor: B.van de Water, Co-promotor: L.S.Price

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Promotie

Het eerste wereldwijde congres over placebostudies van 2-4 april moest uitwijken naar de Stadsgehoorzaal om de deelnemers uit 20 landen te ontvangen. Ook de Nederlandse media lieten zich niet onbetuigd. Bekijk een selectie uit het nieuws met Andrea Evers over placebo's en conditionering.

Op woensdag 5 juli 2017 organiseerden de Afdeling Jeugdrecht en het Grotius Centre for International Legal Studies van de faculteit der Rechtsgeleerdheid een feestelijke borrel ter ere van het 5-jarig bestaan van de ‘Frontiers of Children’s Rights’ summer school. De summer school heeft sinds de oprichting…