De overgang naar ouderschap is een belangrijke fase in de ontwikkeling van de levenscyclus die gepaard gaat met veel veranderingen zowel op persoonlijk als op gezinsniveau. De transitieperiode naar het ouderschap wordt daarmee gezien als een window of opportunity voor opvoedingsinterventies. Bestaande…

De detentie van een ouder heeft grote invloed op kinderen. Daarom krijgen de penitentiaire inrichtingen in Leeuwarden en Veenhuizen een speciale ‘vadervleugel’. Dit is een plek waar vaders hun kinderen kunnen zien en zo meer betrokken kunnen blijven bij hun gezin.

Promotor: T. H. Oosterkamp

De Landelijke Werkgroep Kind en Ouder in de Strafrechtsketen (KOS) heeft als doel de zichtbaarheid en behandeling van ouders en kinderen in de Nederlandse strafrechtsketen te verbeteren door een combinatie van centralisatie, advies en onderzoek.

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Planets are formed in disks of gas and dust around young stars.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Within the field of astronomy, understanding how galaxies grow and evolve from the Big Bang to the present day is a challenging and complex question.

Promotor: B. van de Water

Promotor: J.N. Kok, Co-promotor: M.S. Lew

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Bega je een misdrijf, dan krijg je een passende straf; elke rechtsstaat kent dat uitgangspunt. Maar wat precies rechtvaardige en effectieve straffen zijn, daarover lopen meningen sterk uiteen. Onderzoek door de Universiteit Leiden voorziet politici, wetgevers, handhavers en het publiek van nieuwe informatie…

Hoe beter de behandeling van gedetineerden, hoe effectiever de gevangenisstraf, zo blijkt. Leidse criminologen onderzoeken daarom hoe detentie kan worden verbeterd, onder meer op gebied van leefklimaat en contact tussen gedetineerden en hun kinderen.

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

The global agri-food system plays a critical role in food security and environmental issues.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: P.M. Brakefield

De podcastserie Interculturele Pedagogiek is ontwikkeld door Judi Mesman voor het vak Interculturele aspecten van opvoeding, onderwijs en hulpverlening binnen de Opleiding Pedagogische Wetenschappen van de Universiteit Leiden. Zij interviewt in deze serie professionals werkzaam in het brede jeugdveld.…

Hoe veranderen aankomende vaders tijdens de zwangerschap? Spelen daarbij hormonen een rol en welke effecten hebben die hormonen op het brein van de aanstaande vader? Wordt u dit jaar of begin 2017 voor het eerst vader? Help ons mee inzicht te krijgen in de effecten van hormonen op het aankomend vaderschap…

Do selenium nanoparticles in fish food cause subtle alterations in behavior of fish: effect of particles size and concentration?

Nederland is niet geëmancipeerd als het op zorg voor jonge kinderen aankomt. Wetenschapsjournalist Tonie Mudde van de Volkskrant gaf zichzelf en zijn baby op voor een onderzoek naar vaderschap van Pedagogische Wetenschappen en doet hier verslag van.