Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

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A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.

De Universiteit Leiden vindt de aanpassing van het bindend studieadvies geen verstandig plan.

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Mocht je nog met bepaalde vragen zitten en je wilt graag met iemand spreken, dan biedt Universiteit Leiden hiervoor verschillende opties.

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

De taken van de Raad van Advies

Bachelor, Master

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Een ambtenaar die wordt vervolgd, kan worden ontslagen ondanks dat hij is vrijgesproken. En soms kan een burger die een vergunning heeft gekregen hier toch geen gebruik van maken zonder onrechtmatig te handelen jegens zijn buurman. Hoe gaat een rechter om met een uitspraak van een collega-rechter?

Museums, Collections & Society heeft een Adviesraad.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…

During the course of drug discovery translational steps are made.

To deliver a Virtual Sensor tool optimised to exploit the synergy between Sentinels 2 and 3 to allow the consistent retrieval of land surface parameters (Albedo, LAI, and LST); To extend the existing capabilities of land EO data assimilation tools to add capacity to handle data in the thermal domain…

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

Promotores: F.H.J. Redig, W.T.F. den Hollander

Promotor: Prof.dr. G.P. van Wezel

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotor: B.van de Water, Co-promotor: L.S.Price

Zowel de universiteiten als het ministerie van Onderwijs willen dat studenten op tempo studeren. Hoe zorg je daarvoor? De bacheloropleiding Life Science and Technology heeft de laatste jaren een flinke vooruitgang geboekt.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

De Universiteit Leiden stopt per direct met het experiment bindend studieadvies in het tweede studiejaar (BSA-2). Studenten moesten in BSA-2 binnen twee jaar 90 studiepunten halen, inclusief hun propedeuse.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

Op 10 juni 2021 verdedigde Merinda Stewart haar proefschrift 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. J.J. Rijpma.

Op 19 september 2019 verdedigde Lynette Janssen zijn proefschrift 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. Het promotieonderzoek is begeleid door promotoren prof.mr. W.A.K. Rank en prof.mr. M. Haentjens.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Centraal in dit proefschrift staan de perspectieven van docenten met betrekking tot zelfstandig leren.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

In dit artikel heeft Lianne Visser bijgedragen aan het begrip rondom samenwerkend bestuur als uitdagende aanpak voor hardnekkige problemen.

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.