119 zoekresultaten voor “patients” in de Publieke website
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Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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Livestream promotie
Op deze pagina kunt u promoties van onderzoekers van de Universiteit Leiden live volgen via streaming video.
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Wetenschappelijke publicaties
Onder vindt u de wetenschappelijke publicaties van het Navigatie Lab Leiden
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Promovendus gebruikt AI om onbekende bijwerkingen op te sporen in patiëntenfora
Op patiëntenfora delen patiënten van alles over hun ziekte: van bijwerkingen en adviezen tot steunbetuigingen. Promovendus Anne Dirkson maakt gebruik van Kunstmatige Intelligentie (AI) om deze informatie op te halen. ‘Negentig procent van de bijwerkingen wordt niet officieel geregistreerd.'
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Fulltime programme
Het schema hieronder geeft het curriculum weer van het eenjarige fulltime programma van de master Health, Ageing and Society in collegejaar 2024-2025.
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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On the road to better care for patients with systemic sclerosis
Promotie
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Accelerated Partial Breast Irradiation in elderly patients with early-stage breast cancer
Promotie
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Multimodality imaging in patients with valvular heart disease and systemic diseases
Promotie
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Genomic driven treatment and drug rediscovery in patients with advanced cancer
Promotie
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Triage of stroke patients in the chain of acute stroke care
Promotie
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Advanced echocardiography in characterization and management of patients with secondary mitral regurgitation
Promotie
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Management of disturbed homeostasis in critically ill patients and influence on outcome
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From reactive to proactive: implementing palliative care for patients with COPD
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optimal oncolytic virus treatment and diagnostics in high risk melanoma patients
Promotie
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Glottic insufficiency in patients with vocal fold atrophy with or without sulcus; treatment modalities and outcome
Promotie
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MRI for planning and characterization of uveal melanoma patients treated with proton beam therapy
Promotie
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Comprehensive measurement of long-term outcomes and costs of rehabilitation in patients with stroke
Promotie
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Biomarkers for the response to immunotherapy in patients with non- small cell lung cancer
Promotie
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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scintigraphy and immune modulation. Moving towards a new era for patients with ITP
Promotie
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Innovative diagnostics and treatments
Hoe meer we leren over een (neuro-)psychologische of lichamelijke aandoening en de hieraan gerelateerde gedragsfactoren, hoe beter we deze niet alleen kunnen signaleren, maar ook behandelen. Het is dus belangrijk dat recente inzichten over (neuro-)psychologische problemen en daaraan gerelateerde gedragsfactoren…