2,944 zoekresultaten voor “werkt in security policy and practice” in de Publieke website
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Universal adelic groups for imaginary quadratic number fields and elliptic curves
Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)
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The dust and molecular gas in the torus of NGC 1068
An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.
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Non-equilibrium chemistry and cooling in simulations of galaxy formation
Promotor: J. Schaye
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as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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The optimization and scale-up of the electrochemical reduction of CO₂ to formate
Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…
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“This Path Is Full of Thorns”: Narrative, Subjunctivity, and HIV in Indonesia
In this article, Samuels focuses on the active fostering of subjunctivity in processes of narrative worldmaking. Drawing extensively from the narrative of an HIV‐positive woman in Indonesia, she shows that by subjunctively leaving open multiple narrative trajectories and future possibilities, individuals…
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The dynamic organization of prokaryotic genomes: DNA bridging and wrapping proteins across the tree of life
Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.
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Electrocatalysis of CO2/CO interconversion and Hydrogen Evolution in Bicarbonate Buffers
Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.
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Mind the gap: gas and dust in planet-forming disks
Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond
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Innate immunity, developmental speed and their trade-offs in two hexapod models
This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.
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Cosmic particle acceleration by shocks and turbulence in merging galaxy clusters
In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).
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Hoe vorm je een veerkrachtige samenleving? Anne-Laura van Harmelen legt het belang van vriendschap uit
De hedendaagse uitdagingen van onze maatschappij vragen om een veerkrachtige samenleving. Vriendschappen spelen een belangrijke rol bij het nemen van stappen naar een veerkrachtiger samenleving. Hoe dit werkt? Anne-Laura van Harmelen (hoogleraar Brein, Veiligheid en Veerkracht) legt in opiniemagazine…
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Towards High Performance and Efficient Brain Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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Probing the darkness: the link between baryons and dark matter
Promotor: Prof.dr. J. Schaye, Co-promotor: Marcello Cacciato
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Liberal Arts and Sciences: Global Challenges (BA/BSc)
Bij Leiden University College The Hague staan Global Challenges centraal. Global Challenges zijn de grote, maatschappelijke uitdagingen van de 21ste eeuw waar we gezamenlijk een oplossing voor moeten vinden, zoals klimaatverandering, armoede, ongelijkheid, vrede en recht. Onze opleiding is opgesplitst…
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Online Course International Law in Action: Investigating and Prosecuting International Crime
This course provides an insider perspective into the work of international criminal courts and tribunals. You will learn about the investigation and prosecution of international crimes in The Hague.
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Environmental assessment and guidance for the future offshore wind energy development
This thesis aims to address offshore wind energy (OWE)-related environmental impacts.
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Politics, Culture and National Identities, 1789 to the Present (research) (MA)
De specialisatie Politics, Culture and National Identities, 1789 to the Present (research) van de Universiteit Leiden brengt je in de voorhoede van de nieuwe benadering van de manier waarop in Europa politiek en identiteit worden opgevat.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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The mixed Ax-Lindemann theorem and its applications to the Zilber-Pink conjecture
Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)
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Spin-momentum locking in oxide interfaces and in Weyl semimetals
Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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The electrochemical reduction of dioxygen and hydrogen peroxide by molecular copper catalysts
The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…
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multi-objective optimization of software architecture design: method, tool, and application
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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An Online Corpus of UML design models: Construction and empirical studies
Promotores: J. Kok, M. Chaudron (Chalmers University)
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Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
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against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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galaxy clusters collide: the impact of merger shocks on cluster gas and galaxy evolution
Promotor: Prof.dr. H.J.A. Rottgering
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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Algorithm selection and configuration for Noisy Intermediate Scale Quantum methods for industrial applications
Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.
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additional signals on genes: on the combination of DNA mechanics, genetics and translation speed
DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.
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there yet? Advances in anytime-valid methods for hypothesis testing and prediction
Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…
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Hydrocarbons in interstellar ice analogues: UV-vis spectroscopy and VUV photochemistry
Promotor: Prof.dr. H.L.V. Linnartz
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Making the invisible visible: paramagnetic NMR and the transient protein complex
Promotor: Prof.dr. M. Ubbink
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Magnetic imaging of spin waves and magnetic phase transitions with nitrogen-vacancy centers in diamond
The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Effects of slug herbivory on seedling recruitment in Brassica napus and B. rapa
Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.