The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Hoe beinvloed de structuur van één enkel gen de activiteit van genen die gevoelig zijn voor hormonen?

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Het onderzoeksprogramma Probability Theory richt zich op kansrekening en op operationeel onderzoek.

Promotor: H.W. Lenstra, Jr., Co-promotor: B. de Smit

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Het onderzoek binnen het Algebra, Geometry and Number Theory programma varieert van fundamentele wiskundige theorie tot algoritmes en toepassingen.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotie

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

Promotor: Prof.dr. G.P. van Wezel

In de masterspecialisatie Algebra, Geometry and Number Theory verbreed je je kennis van de zuivere wiskunde met onderwerpen als getaltheorie, algebraïsche meetkunde, algebraïsche topologie en cryptologie.

De masteropleiding Cultural Analysis: Literature and Theory van de Universiteit Leiden richt zich op de studie van literatuur vanuit een vergelijkend en theoretisch perspectief, en onderzoekt de literatuur van een breed spectrum van talen en culturen uit de hele wereld.

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

In deze masterspecialisatie houd je je bezig met twee kernthema’s in de politieke filosofie: legitimiteit en rechtvaardigheid. Je verdiept je in theoriën, methoden en complexe casus en maakt de stap van opinie naar analyse.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

This six-weeks online course delves into the research behind terrorism as it unpacks the assumptions and impacts of both terrorism and counterterrorism.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

In deze studie onderzoeken we of 2-3-jarigen in staat zijn te anticiperen op het gedrag van een personage door rekening te houden met wat dit personage wel of niet weet over de situatie. Het kind zit op schoot en krijgt animaties te zien met twee personages, waarbij de ene zich verstopt en de andere…

Promotor: J. Zaanen

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Op 16 april 2020 verdedigde Andrew Fink zijn proefschrift 'The Importance of Conspiracy Theory in Extremist Ideology and Propaganda'. Het promotieonderzoek is begeleid door promotor prof.dr. A. Ellian.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Promotie

Femke Bakker, Hawks and Doves: Democratic Peace Theory Revisited

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Hoe kunnen we de mysteries van quantummaterie verklaren?

Professor Edwin Bakker, directeur van het Centrum voor Terrorisme & Contraterrorisme heeft zijn nieuwe boek getiteld 'Terrorism and Counterterrorism Studies: Comparing Theory and Practice' bij Leiden University Press uitgebracht.

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

Het boek biedt verschillende theoretische perspectieven om het proces van publieke sector hervormingen te onderzoeken. Daarnaast geeft het een overzicht van de belangrijkste trends in publieke sector hervormingen in Europa en de Verenigde Staten.

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Cognitive enhancement is het gebruik van elke methode of techniek met als doel het verbeteren van cognitieve prestaties.

Het onderzoek gaat over de vraag op welke wijze en op welk niveau studenten van de opleiding voor leraar basisonderwijs theorie en praktijk kunnen integreren en hoe de inrichting van hun leeromgeving, toegespitst op het vak rekenen-wiskunde en didactiek, daaraan kan bijdragen.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Op 12 mei 2020 verdedigde Darryl Robinson zijn proefschrift 'Exploring Justice in Extreme Cases: Criminal Law Theory and International Criminal Law'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.