710 zoekresultaten voor “human” in de Publieke website
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Functional study of the human genome
Promotie
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Towards High Performance and Efficient Brain Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Liselotte Rambonnet
Wiskunde en Natuurwetenschappen
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Thromboinflammation in high-risk human populations
Promotie
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The Monetary Valuation of Water-related Ecosystem Services
While ecosystems have concrete benefits for human society, these benefits are typically overlooked in decision-making.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Life Cycle Assessment of Nanomaterials and Risk Assessment.
What is the environmental impact, the human health impact and the life cycle and production costs of the lab, pilot and commercial diffusion of nanowires and nanowire-based photovoltaic technologies?
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Martin Sievert
Faculteit Governance and Global Affairs
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Suzan van de Velde
Faculteit Archeologie
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Lianne Baars
Faculteit Rechtsgeleerdheid
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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Satellite remote sensing of plant functional diversity
Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
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Atlas van het brein
Onderzoekers werken al eeuwen aan een atlas van het brein. Maar zelfs in 2017 zijn sommige hersenstructuren nog niet in kaart gebracht, met name in de hersenstam. In dit paper hebben we de test-hertest betrouwbaarheid gemeten van de enige MRI-scan die onderzoekers in staat stelt om de locus ceruleus,…
- Microplastics
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Faculteit der Rechtsgeleerdheid
Het onderzoek binnen de Faculteit der Rechtsgeleerdheid beperkt zich niet tot een enkel speerpunt, maar richt zich op de volle breedte van het recht. Door actuele onderwerpen (zoals kinderrechten, politiek, sport, rampen of criminaliteit) te behandelen en te koppelen aan de wetenschappelijke theorie,…
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The European Court of Human Rights reading between the lines
Lezing
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Empirical signatures of universality, hierarchy and clustering in culture
In this thesis,
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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#HumanRightsWeek: Mr. Michael O'Flaherty - What future for human rights?
Lezing
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Starter grant 1
EU human-centered digital
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Mariana Gkliati voorzitter bij ‘Europe on Trial'
Op 2 juni heeft Mariana Gkliati deelgenomen aan het debat ‘Europe on Trial' in De Balie.
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Building bridges: a multidisciplinary approach to controlled human hookworm infection
Promotie
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Aged human osteochondral explants as biomimetic osteoarthritis model
Promotie
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Non-invasive assessment of human brown adipose tissue
Promotie
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Andere publicaties
Andere COI-publicaties zijn te vinden op Leiden Law Blog, de Leiden Law Methods Portal en in het drop-down-menu hieronder.
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Moderne mens eerder in zuiden van China dan in Europa
In Nature beschrijven onderzoekers van de universiteiten van Leiden en Utrecht hoe 47 tanden uit Zuid-China aantonen dat de anatomisch modern mens minimaal 80.000 jaar geleden in die regio aanwezig was. 40.000 jaar eerder dan in Europa.
- Filosofie van de mensenrechten
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Duurzaamheid in onderwijs
De universiteit streeft ernaar dat alle studenten in hun opleiding kennismaken met duurzaamheidsthema’s en -vraagstukken, die zoveel mogelijk aansluiten bij de inhoud van hun opleiding.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?
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EU Erasmus+ Curriculum Development in Data Science and Artificial Intelligence
LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.
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Chemical Similarity: Structuring Risk and Hazard Assessment
At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.
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Bayesian learning: challenges, limitations and pragmatics
This dissertation is about Bayesian learning from data. How can humans and computers learn from data?
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Plant occurrence in space and time: the importance of land use, habitat structure, and pollination mode
Plant diversity is essential for us and our planet as it sustains the stability of our ecosystems, provides vital materials and food to us and supports many ecosystem services.
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.