Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

De minor Creative Strategies for a Society in Change (CSSC) legt een verbinding tussen het verkrijgen van inzicht in creatieve maakprocessen en het verkennen van maatschappelijke problematieken die kenmerkend zijn voor onze tijd.

‘Of we nog een beetje kunnen aanschuiven, dan passen we er allemaal in.’ Uit het hele land komen mensen voor een interactieve dag over het sociale brein. Zes breinwetenschappers weten wat er leeft, blijkt op 6 november j.l. tijdens het publiekssymposium van het Leiden Institute for Brain and Cognition…

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IIn dit artikel blazen Jeroen Wolbers en Sanneke Kuipers het academische debat over rampenparaatheid nieuw leven in.

M van der Stelt

Hetterscheid

Het Leiden University Centre for the Arts in Society (LUCAS) is wereldwijd een van de weinige onderzoeksinstituten waar wetenschappers op het gebied van literatuur, beeldende kunst, architectuur, design en mediastudies samenkomen om onderzoek te doen naar de culturele productie van de westerse wereld,…

This thesis takes steps toward understanding the interaction between gas-phase and solid-state molecules in star- and planet-forming regions.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Kunnen landen bij gebrek aan een sterk internationaal kader voor milieubescherming unilateraal optreden om het wereldwijde milieu te beschermen?

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

Promotie

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Deelproject van

Prof. Bob Wessels, die vorig jaar tot hoogleraar internationaal insolventierecht met emeritaat ging is benoemd als External Scientific Fellow van het Max Planck Institute Luxembourg for International, European and Regulatory Procedural Law.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

The LIACS Media Lab has received a research grant from the worldwide leading graphics hardware company NVIDIA. The grant exists of newly developed hardware utilizing thousands of processors. LIACS researchers will use it to investigate deep learning in understanding imagery from sources such as MRI…

Promotor: Prof.dr. J.N. Kok

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Promotor: W.T. de Groot

Promotor: Prof.dr. T.H.W. Bäck

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Promotores: W. Jiskoot, F. Ossendorp

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Multi-criteria optimalisatie is een effectieve techniek voor het vinden van optimale oplossingen die een afweging bieden tussen verschillende, tegenstrijdige criteria. Het heeft zijn toepassing gevonden in de wereld om ons heen omdat bij het oplossen van praktische, re¨ele wereld problemen men gewoonlijk…

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

Gaan hersenaandoeningen als Alzheimer of autisme gepaard met specifieke afwijkingen in de onderliggende communicatienetwerken in de hersenen? Als dat zo is kunnen subtiele veranderingen in die netwerken als marker fungeren voor hersenstoornissen. Neurowetenschapper Serge Rombouts gaat het met een landelijk…

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.