2,747 zoekresultaten voor “evolution and development” in de Publieke website
-
Law and Society (MSc)
In de Engelstalige master Law and Society: Governance and Global Development bestudeer je het functioneren van recht en de werking van rechtssystemen.
-
Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
-
Development of highly accurate density functionals for H2 dissociation on transition metals
Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).
-
Multiple star formation: chemistry, physics and coevality
Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.
-
Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
-
pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
-
Merging galaxy clusters: probing magnetism and particle acceleration over cosmic time
In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.
-
Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
-
of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
-
redesigning a program using characteristics of effective instructional development
Docenten in het hoger onderwijs zijn experts in wát zij doceren, maar niet noodzakelijk in hóe zij dit zouden moeten doen. Dit komt omdat zij vaak weinig tot geen training hebben gehad in het lesgeven. Daarnaast zijn zij over het algemeen meer georiënteerd op hun eigen vakgebied dan op hun rol als docent.…
-
Pre- and perinatal risk factors
Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.
-
PhD student in Biochemistry, Structure and Function of Archaeal Chromatin
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
-
Hydrodynamics and the quantum butterfly effect in Black Holes and large N quantum field theories
Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?
-
Surveying young stars with Gaia: Orion and the Solar neighbourhood
OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.
-
The role of water in hydrogen electrocatalysis
Promotor: M.T.M. Koper, Co-promotor: L. Juurlink
-
A well-established harmony in chaos: from isolated galaxies to galaxy clusters
The origin and evolution of galaxies are closely linked to many different physical phenomena.
-
Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
-
Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
-
Non-linear astrochemical kinetics: theory and applications
This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.
-
The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
-
Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
-
Algorithm for Structural Variant Detection
Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.
-
Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
-
Disentangling a complex genus: systematics, biogeography and bioactivity of the genus Phyllanthus L. and related genera of tribe Phyllantheae (Phyllanthaceae)
The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.
-
Tracing the journey of the sun and the solar siblings through the Milky Way
Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown
-
Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis thaliana
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
-
Ymke de Bruijn
Faculteit Governance and Global Affairs
-
Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
-
Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
-
The connection between mass and light in galaxy clusters
Promotor: Koen Kuijken Co-promotor: Henk Hoekstra
-
Quantum local asymptotic normality and other questions of quantum statistics
Promotor: R. Gill, Co-promotor: P. Massart
-
Probing cosmic monsters: confronting hydrodynamic simulations with new observations of high-density environments
Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.
-
Fundamental research on the voltammetry of polycrystalline gold
Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.
-
Archaeological Heritage and Society
Medewerkers en studenten van het departement Archaeological Heritage and Society van de Faculteit Archeologie onderzoeken welke rol het verleden kan spelen in moderne samenlevingen. Zij willen meer weten over de relaties tussen verleden en heden, en de rol die erfgoed daarbij speelt.
-
Prestigieuze Edinburgh Medal voor 'Astronomy for Development'
De Edinburgh Medal 2016 is uitgereikt aan zowel Kevin Govender van de Office of Astronomy for Development (OAD) als de International Astronomical Union (IAU). De prijs is een erkenning voor het wereldwijd bevorderen van onderwijs en technologie door middel van sterrenkunde. Het programma is het geesteskind…
-
Pre-masterprogramma
Heb je een Nederlands hbo-bachelor- of masterdiploma en wil je de éénjarige masteropleiding Education and Child Studies gaan doen? Dat kan als je het premasterprogramma met succes hebt doorlopen.
-
Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
-
Cities, migration and global interdependence 1350-2000
The research programme Cities, Migration and Global Interdependence 1350-2000 (CMGI) focuses on urbanisation, migration, and economic development in a comparative and global context.
-
Acute and chronic pain after cardiac surgery
Promotores: C.A.J. Knibbe, D. Tibboel, Co-Promotor: P. Bruins
-
Resolving the building blocks of galaxies in space and time
We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.
-
Combining classic and novel tools in the study of Historical Collections of Chinese Materia Medica in the Netherlands
Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…
-
Biophysical feedbacks between seagrasses and hydrodynamics in relation to grazing, water quality and spatial heterogeneity
Consequences for sediment stability and seston trapping
-
Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
-
The parabolic Anderson model and long-range percolation
Promotor: Prof.dr. F. den Hollander, G.Maillard
-
industrial carbon emissions: Historical drivers at the regional and sectoral levels and projections in light of policy targets
Has the industrial sector in China effectively been decarbonizing in recent years, across different regions and subsectors, and is it plausible that it will reduce its CO2 emissions in conformity with national and internationally pledged emission goals?
-
Turtles all the way down: multiscale simulations connecting star and planet formation
The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.
-
Services on Environmental Statistics and Accounts
What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?
-
Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
-
Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
-
Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua