323 zoekresultaten voor “disease prevention” in de Publieke website
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Maria Yazdanbakhsh
Faculteit Geneeskunde
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Nieuwe stoffen remmen ontsteking in het brein
Leidse chemisch biologen, onder leiding van dr. Mario van der Stelt, hebben stoffen ontdekt die ontstekingsprocessen in de hersenen kunnen verminderen. Daarmee is een eerste stap gezet in de ontwikkeling van potentiële geneesmiddelen voor de behandeling van hersenziekten zoals de ziekten van Alzheimer…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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Lipid signaling and inflammation: metabolomics for better diagnosis and treatment strategy
Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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urinary tract infection: definitions, diagnostics, and strategies for prevention
Promotie
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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Multifaceted role of the complement system in health and disease
Promotie
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Role of intestinal microbiota in cardio-metabolic disease
Promotie
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Advanced echocardiographic imaging in valvular and systemic diseases
Promotie
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Early diagnosis and management of celiac disease in childhood
Promotie
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Pharmacotherapy and Ventilatory Control in Health and Disease
Promotie
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Oxidative Stress in Chronic Diseases: Causal Inference from Observational Studies
Promotie
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Viral gene therapy approaches for CRB1 retinal disease
Promotie
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Genetics and Life Course Epidemiology of Cardiometabolic Disease
Promotie
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4D-Flow MRI of Aortic and Valvular Disease
Promotie
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Developmental cell lineage dynamics in Bicuspid Aortic Valve disease
Promotie
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glycocalyx; a diagnostic and therapeutic target in cardiometabolic diseases
Promotie
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Herkenning van kinderen met en at risk voor angststoornissen in de huisartsenpraktijk
Herkennen huisartsen kinderen die (een verhoogd risico voor) angststoornissen hebben en is er een patroon dat kan helpen om kinderen met en zonder angststoornissen te onderscheiden in de huisartsenpraktijk?
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Strategies to Investigate Lipoprotein Metabolism and Combat Cardiometabolic Disease
Promotie
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Antimicrobial Stewardship and Infection Prevention in the Neonatal Intensive Care Unit
Promotie
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Andrea Evers over placebo-effect en conditionering
Het eerste wereldwijde congres over placebostudies van 2-4 april moest uitwijken naar de Stadsgehoorzaal om de deelnemers uit 20 landen te ontvangen. Ook de Nederlandse media lieten zich niet onbetuigd. Bekijk een selectie uit het nieuws met Andrea Evers over placebo's en conditionering.
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Advanced MRI-markers of cerebral small vessel disease
Promotie
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Cardiac CT for diagnosis and prognosis of coronary artery disease
Promotie
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Algorithm for Structural Variant Detection
Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.
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IBL Spotlights
Tijdens de IBL Spotlights bespreken onderzoekers van de afdeling Science Communication & Society hun nieuwste bevindingen en realisaties. Na de lezingen ben je welkom bij de borrel op de eerste verdieping van het Sylviusgebouw.
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Inverse design of curvature-sensing antiviral peptides
Viral diseases constitute one of the major challenges in modern medicine. Membrane-targeting have broad-spectrum potential and could distinguish viral membranes from the host cell plasma membrane by the difference in membrane curvature.
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Modern Drug Discovery
How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…
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What Works in Suicide Prevention? Lessons from the 113 Helpline
Lezing
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Advanced diagnostic tools in congenital heart disease and pulmonary hypertension
Promotie
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Consortium DDMoRE lanceert open-access databank
Bio-farmaceuten kunnen vanaf nu modelcodes en datasets uit een databank opvragen om de dosering en het effect van nieuwe medicijnen beter te kunnen voorspellen.
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Nieuwe planten produceren zonder zaaien
Zonder een gewas opnieuw te zaaien toch nakomelingen produceren, die zelfs groter kunnen zijn dan de ouderplant. Volgens Leidse onderzoekers is dat mogelijk door het overstimuleren van één gen. Daarmee verjongt een cel en gaat deze terug naar de embryonale fase.
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Levensverlengend gen bij planten ontdekt
Oogst na oogst binnenhalen van rijstveld, zonder nieuwe rijstplanten te zetten? Door een ontdekking komt dit scenario misschien wel dichterbij. Leidse wetenschappers hebben een gen ontdekt waarmee ze eenjarige planten na het bloeien opnieuw laten groeien, in plaats van dat de planten sterven. Publicatie…
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‘Onbelangrijk’ plantengen blijkt wel degelijk essentieel
Leidse biologen hebben aangetoond dat een gen dat aanwezig is in planten, dieren en gisten wel degelijk een belangrijke rol speelt in planten, al werd daar jaren anders over gedacht. Zonder het gen blijkt de ontwikkeling van vaatweefsel in planten niet goed op gang te komen. Publicatie in Nature Plants…
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Tackling chronic respiratory disease in low-resource settings
Promotie
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Mechanistic Early Phase Clinical Pharmacology Studies with Disease
Promotie
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Iron-immune interactions in Alzheimer's disease
Promotie