1,202 zoekresultaten voor “is a en samenleving” in de Publieke website
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Semigroups on Spaces of Measures
Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Data-driven Predictive Maintenance and Time-Series Applications
Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.
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Exploring novel regulators and enzymes in salicylic acid-mediated plant defense
Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.
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Trans-kingdom DNA transfer
The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.
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Reactivity and Selectivity in Glycosylation Reactions
The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.
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Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
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Workshop The Art of Journaling
Kunst en vrije tijd, Kunst en vrije tijd
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Genomics applications of nanopore long-read sequencing for small to large sized genomes
In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…
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Ecological functions and environmental fate of exopolymers of Acidobacteria
Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.
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The parabolic Anderson model on Galton-Watson trees
The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.
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‘Juist als er schandalen zijn gaat het goed met de samenleving’
Waar de Rekenkamer vroeger eens per jaar een onderzoek uitvoerde, krijgt de gemiddelde ambtelijke organisatie er tegenwoordig een paar per jaar te verwerken. Is dit nodig omdat er tegenwoordig zoveel fout gaat? Welnee, betoogt bijzonder hoogleraar Sjoerd Keulen.’
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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The LUGO Press
The LUGO Press is a student publication forum, rooted in academia and journalistic practices and published by the Leiden University Green Office.
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Online Course Clinical Kidney, Pancreas and Islet Transplantation
Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.
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Faculteiten
De Universiteit Leiden, in 1575 opgericht, is een van Europa’s meest vooraanstaande internationale onderzoeksuniversiteiten. Haar motto is Praesidium Libertatis – Bolwerk van Vrijheid.
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Onderzoek
Wetenschappelijk onderzoek naar kolonialisme en slavernij wordt gedaan vanuit verschillende onderzoeksprogramma's en verschillende disciplines.
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Universe Awareness’ Universe in a Box wint prijs Beste Lesmateriaal voor Wetenschapseducatie
Universe in a Box is erkend voor zijn educatieve waarde, door het Europese netwerk van Wetenschapseducatie (Scientix).
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Instituut voor Metajuridica
Wat het recht is, weten de meeste mensen wel. Maar wat het recht zou moeten zijn of waar het vandaan komt, is voer voor de onderzoekers van het Instituut voor Metajuridica. Centraal in hun benadering staan onderwerpen die een diepere, rechtsfilosofische kern raken. Wat is een staat? Waar liggen de grenzen…
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Data science and sports: a winning combination
Athletes always strive for the top. How can data scientists assist them in improving their performance? During the seminar Data Science and Sports, the possibilities and challenges of collaboration between these two worlds were discussed.
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Christoph Niessen
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Paul Cliteur
Faculteit Rechtsgeleerdheid
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Public Administration
Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.
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Identification of Therapeutic Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotor: G.J.B. van Ommen
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Carels universum: Leidse musea verbeelden rectoraat Carel Stolker
Tien Leidse musea en erfgoedinstellingen maakten samen de online tentoonstelling ‘Carels universum’. Ze kozen objecten uit hun collectie die volgens hen symbool staan voor scheidend rector Carel Stolker en het onderzoek in Leiden. Met directe verwijzingen, speelse associaties en een enkele knipoog.
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Prof.dr. A.M. Dogterom in DWLD
Hoe vermenigvuldigen de miljoenen cellen in ons lichaam zich precies? Prof. Dogterom legt uit hoe zij een onderdeel van een cel heeft kunnen nabouwen op een chip met deeltjes ter grootte van een nanometer.
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Waste Collection Systems Assessed and Good Practices Identified (COLLECTORS)
What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?
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Class invariants for tame Galois algebras
Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit
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Cryptography from quantum uncertainty in the presence of quantum side information
Promotor: Ronald Cramer, Co-promotor: Serge Fehr
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Optimally weighted ensembles of surrogate models for sequential parameter optimization
It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.
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Indicators for "decoupling"
Indicators to measure progress in de-linking economic growth and environmental pressure.
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Topics in the arithmetic of del Pezzo and K3 surfaces
Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Algorithms for finite rings
Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)
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Statistical physics and information theory for systems with local constraints
Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.
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Quality-driven multi-objective optimization of software architecture design: method, tool, and application
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich
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Understanding disease suppressive soils
Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Automated machine learning for dynamic energy management using time-series data
Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…
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De samenleving betrekken bij ons onderzoek en onderwijs: hoe staat het ervoor aan de Universiteit Leiden?
Misschien ken je het als citizen science. Of misschien ken je het als volunteer mapping, patient co-researcher, of zelfs community engaged learning. Participatief onderzoek en onderwijs hebben veel verschillende namen, maar welke jij ook kiest: weet dat er veel van dit soort open science gaande is bij…
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Grensoverschrijdend verkeer t.a.v. moreelgevoelige onderwerpen
Homohuwelijk, draagmoederschap, abortus. Hoe reageert het recht op dergelijke moreelgevoelige onderwerpen bij grensoverschrijdend verkeer binnen de Europese Unie? Op 4 november 2015 promoveert Nelleke Koffeman op dit onderwerp.
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Maken en creëren met eeuwenoude kennis
Het vermogen om voorwerpen en bouwsels met de hand te maken, is essentieel geweest voor de ontwikkeling van de mens. De moderne samenleving dreigt dat vermogen te verliezen. Leidse archeologen verzamelen kennis over processen van ‘maken en creëren’ door de eeuwen heen. Die kennis helpt onze huidige…
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Learning class-imbalanced problems from the perspective of data intrinsic characteristics
The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.
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Imaging polarimetry for the characterisation of exoplanets and protoplanetary discs. Scientific and technical challenges
Promotor: Prof.dr. C.U. Keller
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EXIOBASE
EXIOBASE is a global, detailed Multi-regional Environmentally Extended Supply and Use / Input Output (MR EE SUT/IOT) database. It was developed by harmonizing and detailing SUT for a large number of countries, estimating emissions and resource extractions by industry, linking the country EE SUT via…
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Algorithm for Structural Variant Detection
Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.