Promotie

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

Promotores: G.A. Persoon, H.H. de Iongh

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Promotores: F.H.J. Redig, W.T.F. den Hollander

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Twaalf Leidse onderzoekers ontvangen restgelden in het kader van ILS 2.0. Met dit onderzoeksgeld kunnen zij zich richten op het voorbereiden van subsidievoorstellen en het ontwikkelen van nieuwe onderzoekslijnen.

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

In this thesis, classes of strongly interacting quantum field theories, have been studied.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotor: R.D. Gill, F. Taroni

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez.

Op 21 september gaf Magdalena Jozwiak, onderzoeker bij eLaw - Centrum voor Recht en Digitale Technologie, een presentatie over het e-SIDES project tijdens een ILS Lunch Seminar.

Het profileringsgebied Interaction between Legal Systems is multidisciplinair en stimuleert innovatief onderzoek met een inhoudelijke focus op de interactie tussen rechtsstelsels. Voor de komende onderzoeksperiode 2016-2020 zijn uit alle inzendingen drie winnende projecten geselecteerd.

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

Promotor: Prof.dr. S.F. Portegies Zwart

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

Promotor: W. Jiskoot, Co-promotor: A. Kros

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.

Promotor: Prof.dr. S. Haring

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

In het kader van ILS 2.0 zijn er restgelden beschikbaar voor het indienen van subsidievoorstellen en - direct daaraan gekoppeld en inherent daaraan - het ontwikkelen van nieuwe onderzoekslijnen. Per aanvraag geldt een maximumbudget van 40.000 euro. In totaal is 180.000 euro beschikbaar voor deze cal…

Op vrijdag 24 februari zal Prof. Judith Masson (Bristol University), Hoogleraar Rechtssociologie en Fellow bij the UK Academy of Social Science, een lezing geven binnen de Leiden Socio-Legal Series.

This interdisciplinary minor addresses sustainabilty challenges from a systems perspective, and investigates ways to sustain society within planetary boundaries.