Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

A neolithic settlement on the Dutch North Sea coast c. 3500 CAL BC.

In this article, the authors summarise the literature on the effects of multilevel governance on governments’ policy responses to Covid-19.

The article offers a comparative systematic literature review of the principles, norms, and strategies associated with Security by Design and Privacy by Design

At ACPA, the collaboration between Leiden University and the University of the Arts The Hague, artistry and academia meet at the highest level.

This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.

Pottery traditions and social interaction in the earliest Neolithic of the Lower Rhine Area

Is it possible to synthesize industrially relevant compounds in a sustainable manner through the use of light-capturing cyanobacteria?

The sites of Norman Estata, Anse des Pères and Hope Estate with a contribution to the 'La Hueca problem'

Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Doctoral Thesis

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

How can we make agricultural production systems more sustainable as the worldwide demand for healthy, safe food continues to grow? How can we develop healthy new food crops that have higher yields while requiring fewer harmful chemicals?

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

M. Danhof, Co-promotor: O.E. Della Pasqua

PhD defence

Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and bio(photo)catalysis in synthetic cells.

Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…

PhD at Université de Picardie Jules Verne, Amiens - France

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

In the Catalysis and Surface Chemistry group, we investigate how catalysis works on the molecular level. The group is divided in six subgroups, focusing on different aspects of heterogeneous catalysis, homogeneous catalysis and electrocatalysis.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

What are the phylogenetic relationships among the members of speciation bursts?

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Source: PLoS ONE, Volume 10, Issue 3 (2015)

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Daily management at the Institute of Biology Leiden is executed by the Scientific Director, the Director of Education, the Director of Operations and the Management Assistant. Research and education are managed collaboratively, with strategic input from various representatives and gremia, including…

Conact the Cellular Chemistry group

Biology is the study of life. Are you interested in understanding life, from the molecular level to entire ecosystems? Do you want to use your understanding and knowledge of biology to benefit the health of both humans and the environment? If so, Biology is the right study programme for you.

Hass

The Metabolomics Facility of the University of Leiden has brought together two research groups from the Faculty of Science that are well-known for their expertise in two different fields: the Biomedical Metabolomics Facility Leiden, experts in clinical metabolomics and the Natural Products Laboratory,…

The Royal Netherlands Academy of Arts and Sciences has elected five Leiden professors from different disciplines as new members. Two of the new members are women.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.