Key publications of the Predictive Pharmacology group.

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

This thesis is based on five papers on several topics.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

The Science, Management and Innovation (SMI) group examines organisational dynamics governing the management of complex R&D projects and technology commercialisation.

We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Research projects

This thesis explored the question whether Scrum methodology might function as an appropriate scaffold to enhance students’ learning and to support teachers in context-based secondary chemistry education.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

KIGS is a research project on communication patterns in the social sciences and humanities. Counting of publications and citations are common methods to measure international scientific impact. Based on citation analyses, various calculation methods and indicators have developed in recent years. However,…

How do learners engage during project-based learning (PBL) and what is the impact of PBL on their learning outcomes?

This proposal aims at the construction of a comprehensive and authoritative scientific grammar for Dutch and Frisian in the form of a virtual language institute: het Taalportaal/the Language Portal.

Promotor: Prof.dr. T. Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron, Co-Promotor: P. van der Putten

Animal Sciences’ contribution to the Bioactive Molecules research theme includes research on molecules from natural sources, such as plants, insects, and snake venom, with the aim to identify novel anti-cancer, anti-inflammatory, anti-microbial, and anti-diabetic agents.

In this work, we attempt to answer the question:

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

This paper examines the need and possibility for developing online resilience-based approaches in response to COVID-19 vaccine conspiracies, often linked to the far right.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

On the 9th of April, Manolis Fragkiadakis successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Manolis on this achievement!

This master specialisation is ideally suited as a basis for starting a research career at a university or research institute and for a position in a bioscience-based company.

The Leiden LIS Sectoral Income Inequality Dataset, assembled by Chen Wang, Stefan Thewissen and Olaf van Vliet (Version 1.1, March 2014), contains information on multiple indicators of earnings inequality and employment within 9 sectors and 12 subsectors, drawing upon micro data from Luxembourg Income…

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

The effect of the pilot Teen courts will be evaluated by means of a programme, process and effect study based on qualitative research methods.

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

How did people in the latter part of the Late Bronze Age organize themselves in order to be able to erect massive structures such as tholos tombs, citadels and how did they interact with these materials and circumstances while constructing? What impact did such a changing landscape have on their day-to-day…

How can we broaden youth participation in STEM Learning

Our mission: a positive impact. Our vision: community. By involving the world around us in our education and research we make a positive impact. We do this by applying Open Science.

This paper explores whether multilateral surveillance and policy coordination under the ES was based on a path-changing or a path-dependent mechanism

There is little evidence of the routes connecting Amerindian communities in the Caribbean prior to and just after 1492. Uncovering possible canoe routes between these communities can help to explain the structure, capabilities, and limitations of the physical links in their social and material networks.…

Digital Archaeology is concerned with digital data for for archaeological research, and the computational methods and tools required to collect, analyse and manage it.

The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Research and design are becoming more and more important in international science education. In The Netherlands, two recently introduced subjects focus on research and design activities in the classroom: O&O (research and design) and NLT (nature, life and technology). This research aims to look at what…

Key publications of the Quantitative Clinical Pharmacology group

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

With our research, we aim to enrich academic and practical knowledge on the governance of sustainability, as well as contribute to public debates on these issues. For that purpose, we strive for diversity in our research subjects, research methods and theoretical approaches. Our research covers different…

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek