In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Leiden has a strong tradition in theoretical physics, thoroughly linked with experimental disciplines.

Social anxiety and factors determining school success in children. Brain development in relation to cognitive, social and emotional development in adolescence.

Effects of age and social anxiety

Source: PLoS ONE, Volume 10, Issue 3 (2015)

What role play stress and fear in forming of nocebo hyperalgesia?

Sound & Score brings together music expertise from prominent international researchers and performers exploring the intimate relations between sound, score and notation, and the artistic possibilities that this relationship yields for performers, composers and listeners.

To what extent can literary strategies deepen and enhance research in and through the visual and performing arts, as well as for research in academia?

In this study Lilie Roosman describes the effects of prominence and boundary marking on the temporal and melodic structures of two regional languages of Indonesia, viz. Toba Batak, a stress language, and her native language Betawi Malay, a non-stress language.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

This zine is an experimentation in layering and juxtaposition as bonding relations of care by Federico de Musso.

Leiden archaeologists have set fire to a reconstructed Neolithic house in Horsterwold: all in the name of science. Studying the remains will help them understand present and future finds.

Sustainable energy from wind and solar is most readily available near the sea.

This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

The Iraqi archaeological site of Nimrud was recently recaptured from IS. The site has been severely damaged. The question now is, what to do with it? Should it be restored? Bleda Düring spoke with Trouw about this complex issue.

Lecture

What did our distant ancestors eat and how did they prepare their food? For the length of a month, experimental archaeologist Diederik Pomstra subjects himself to a rigorous palaeodiet. He is vlogging about his experiences to reach a non-academic audience.

Neanderthals were able to make fire on a large scale with the aid of pyrite and hand-axes. This means they could decide when and where they wanted fire and were not dependent on natural fire, as was thought earlier. Archaeologist Andrew Sorensen has discovered the first material evidence for this. Publication…

PhD defence

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

The Physics and Quantum Matter and Optics specialisation is one of the two programmes Leiden offers in experimental physics. The programme can be tailored to individual needs and interests.

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…

ELS@Leiden research encompasses a wide range of empirical-legal projects carried out within Leiden Law School from the perspective of multiple disciplines and methods. Here you can find the publications of our (former) lab members since the start of the Sector Plan.

Publishing an article as early as during your studies. Master's students of Nanne Timmer and Astrid Weyenberg are doing it. In the new course 'Leiden Graduate Journal Culture and Society' they are creating an academic journal.

Snellius, Niels Bohrweg 1, 2333 CA, Leiden

Lecture Hall, Einsteinweg 57, 2333 CC, Leiden

If male budgerigars can successfully open a puzzle box with food, they become more attractive to females. Biologist Carel ten Cate and Chinese colleagues published experimental evidence for this in a paper in Science on 11 January. Various Dutch and international media wrote about the paper.

Microbial Sciences' contribution to the Evolution & Biodiversity research theme focuses on understanding how bacteria sense and respond to their environment, and how bacterial diversity and evolution is influenced by cooperative and antagonistic interactions taking place between microbes.

The drug discovery pipeline is used to describe the stages in drug discovery. The earliest stage concerns with the identification of potential targets and molecules ('hits') that can modulate their function, while more advanced stages are about developing these hits into viable experimental drugs and…

Mechanical interactions between cells and their environment play an important role in many biological processes.

Although it is often assumed that the stereochemistry in Ugi multicomponent reactions is determined in the final Mumm rearrangement step, experimental and computational evidence that Ugi reactions on hydroxylated pyrrolines proceed under kinetic control is reported.

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…

Sense Jan van der Molen is vanaf 1 maart de nieuwe wetenschappelijk directeur van het Leiden Instituut voor Onderzoek in de Natuurkunde.

Without electronics carrying out computational tasks our daily lives would look very different. Devices such as elevators, vending machines, turnstiles, washing machines and even traffic lights use a simple form of electronic computing to switch from state to state. But, what if power supply is not…

Tjerk Oosterkamp of the Leiden Institute of Physics managed to do the first-ever measurement of gravity on a tiny particle - just 0.43 milligrams - where the quantum regime starts. He explains in Physics World why this is so challenging.

Update : August 2017 Dr Harco Willems

Long-distance Trade in Early Medieval Landscapes (ca. 6th-12th centuries)

Lecture, Studium Generale

Wijnhaven, Turfmarkt 99, 2511 DP, The Hague

Considering Mesoamerican Precolonial books as material objects

Birds sing to be heard, but how do they cope with increasing noise levels? Which species persist in cities and why? And do they thrive or suffer in the urban soundscape?

Dive into the heart of archaeological science: explore the flora and fauna of bygone ages, study human bones and teeth, analyse the cultural biographies of material objects, or become an expert in the use of digital data in archaeological research.

Below are some of the scholarly works published within the context of the Institutions for Conflict Resolution programme.