6,432 search results for “based” in the Public website
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Innovative online course on Modelling and Simulation in Archaeology
Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…
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Call for proposals SAR conference 2016
The International Conference on Artistic Research, organised by the Society for Artistic Research, will take place in The Hague on 28 & 29 April 2016.
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MCBIM Colloquium: Metal-Modified Nucleic Acids: From Silver(I)-Mediated Base Pairs to Phosphorescent Platinum(II)-Bearing DNA
Lecture
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From inquisitive exchange student to Californian dream job
As an exchange student, alumna Jessica Ma was already looking for a bridge between statistics and the real world. In Leiden, she gained the experience to follow her interests and, after a few detours, she landed her ideal job with Disney in the United States.
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Generalized Strictly Periodic Scheduling Analysis, Resource Optimization, and Implementation of Adaptive Streaming Applications
This thesis focuses on addressing four research problems in designing embedded streaming systems.
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
PhD defence
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Screening the CITY: Optimizing population-based cancer screening in the Netherlands from a primary care perspective
PhD defence
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What’s in the diet? DNA-based analysis for qualitative and quantitative assessment of animal diet
PhD defence
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
PhD defence
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MCBIM Colloquium: Supramolecular systems based on CO2 and metal waste material: from fundamental investigations to recycling plant
Lecture
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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‘Science is always the foundation for finding the best treatment, but we should broaden our scope'
As of 1 August, Anika Bexkens has been appointed Professor of Evidence-Based Clinical Practice for Child and Adolescent Mental Health. Her research focuses on the optimal application of scientific knowledge in practice. ‘Scientists and practitioners often speak past each other.’
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
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A macro level assessment of material circularity
A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.
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Research project The Power of Evidence
Evidence-informed policy-making is crucial for good governance. Yet, despite the abundance of evidence from research and evaluation available to decision-makers, we know little about the actual influence of evidence on government policies. The ‘Power of Evidence’ (PoE) research programme, directed by…
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Patient-Centered Value-Based Healthcare in Long-term Follow-up after Pediatric Stem Cell Transplantation for Nonmalignant Diseases
PhD defence
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From Clinical to Public Health Perspectives. Results from population-based studies of the Dutch and the Indonesian populations
PhD defence
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Adapt or perish – traits identified that help plants survive
PhD candidate Jianhong Zhou aimed to better understand whether and how plant species adapt to environmental changes. She developed two databases that she used to analyze how easily or difficultly plants adapt to changing conditions. Zhou defended her PhD thesis on 4 September.
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The Power of Evidence unravelled in new research programme
Governments and public sector organisations consider evidence-based or evidence-informed policymaking as one of the pillars of good governance. That is to say: policies that are informed by scientific knowledge, expertise and evidence. In the research programme 'Power of Evidence', Valérie Pattyn and…
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Computational aspects of class group actions and applications to post-quantum cryptography
Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Nicholas Vrousalis, 'Exploitation: A Primer'
Political scientist Nicholas Vrousalis (Leiden University) reviews the recent literature on exploitation. He istinguishes between three main species of exploitation theory: (a) teleology-based (including harm and mutual benefit) accounts, (b) respect-based (including mere means, force, rights, and fairness)…
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BIAS: Mitigating Diversity Biases in the Labour Market
The project will investigate the use of Artificial Intelligence in the labour market, and how biases in hiring and promoting processes based on personal characteristics are potentially reproduced with AI-based systems.
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A metabolomics resistance test
Can metabolomic profiling be used to predict resistance against insect herbivores in plants?
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Aquatic eDNA: Beyond Species Presence
As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.
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A game of Mastermind to unravel Alzheimer’s disease
In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…
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Is Michael Meijer the Smartest Chemist of the Netherlands?
He is occupied with the home stretch of his promotion. But in between, there is another challenge: Michael Meijer is going through to the finals of ‘The Smartest Chemist of the Netherlands’. On Tuesday 9 October, he and five others fight for this title during the Evening of Chemistry. ‘I was dragged…
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Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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High-throughput screening for developmental and reproductive toxicity
Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?
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Student for a Day - MSc Crisis and Security Management, spec. Governance of Violence
Study information
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CarbonCap
In the CarbonCap project, consumption oriented technological options and policy measures are identified as an addition to the present EU and world climate policy.
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Novel approaches for direct exoplanet imaging: theory, simulations and experiments
The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.
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Enhanced coinduction
Promotores: J.J.M.M. Rutten, F.S. de Boer, Co-promotor: M.M. Bonsangue
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Stepwise latent class analysis
The main methodological aspects of the use of stepwise LCA estimators under different circumstances.
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From descriptive to predictive pharmacology in children using semi-physiological population modelling: application to hepatic metabolism
Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…
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Former projects
Former clients en projects
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Microfluidics for high-throughput liposome formulation for personalized cancer vaccination
Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Alumni at work
Many Science Based Business students receive their first job offer during or right after their internship.
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Life Cycle Assessment of Nanomaterials and Risk Assessment.
What is the environmental impact, the human health impact and the life cycle and production costs of the lab, pilot and commercial diffusion of nanowires and nanowire-based photovoltaic technologies?
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Education
In a network- and case-based programme on management, business and entrepreneurship we focus on science-driven companies and exploiting business opportunities created by research.
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Child care
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An Online Corpus of UML design models: Construction and empirical studies
Promotores: J. Kok, M. Chaudron (Chalmers University)
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Reactive Copolypept(o)ides as Novel Material for Systemic siRNA Delivery
The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors
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OPENup: Optimizing exposure therapy for Posttraumatic Stress disorder
Although exposure therapy is the gold-standard treatment of posttraumatic stress-disorder (PTSD), only half of the patients adequately benefit from it. Based on recent insights into the mechanisms of extinction, this project examines strategies and techniques to improve exposure treatment outcome in…
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Boetian Landscapes
A GIS-based study for the reconstruction and interpretation of the archaeological datasets of ancient Boeotia
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Do banks have human rights?
On 1 October 2019 the Hazelhoff Centre for Financial law hosted its 19th guest lecture starring Paul Sharma, managing director at Alvarez & Marsal and co-head of the European Financial Industry Regulatory Advisory Services practices.