We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Research at the BIOSYN group is comprised of the following research themes:

Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

PhD defence

Andrew DJ Shield (History) and Ann Marie Wilson (Leiden University College) have been awarded a seed grant for their project, “Transnational Gay/Lesbian Activism since the 1960s.” Granted: €3000.

The Science faculties of Universitas Indonesia (UI) and the Universiteit Leiden signed agreements on Tuesday April 12 that will strengthen cooperation between the Faculties. The agreements were signed at the closing of a two day visit of a delegation from Indonesia. The delegation, which was led by…

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Direct radiocarbon dating of human remains is crucial for the accurate interpretation of prehistory. Yet given the scarcity of prehistoric human remains, direct dating is often too destructive for important fossils. The reduction of sample size necessary for dating bone is therefore of great interest…

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.

During the course of drug discovery translational steps are made.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

The Cell Observatory is run by several people some of which have multiple roles. To identify whom to contact for what issue please refer to the list below

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Promotor: Prof.dr. J.P. Abrahams

Quantitative biology means exploiting mathematical modelling and computer simulation as a tool to gain additional insights into the meaning of experimental data. Discover in this minor when and how to apply these tools, in a multidisciplinary setting.

Through courses and research projects, you are trained by experts in the field.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

If you are interested in Life Science and you are looking for a programme with ample opportunities to put together your own study path, our Life Science and Technology programme is the right choice. The programme focuses on societal problems at the molecular and cellular level.

PhD defence

Unraveling the immune-suppressive actions of drugs like prednisone.

Lecture

Lecture

To be eligible for Molecular, Cellular and Organismal Biology at Leiden University, you must meet the following admission requirements.

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

To be eligible for Molecular Genetics and Biotechnology at Leiden University, you must meet the following admission requirements.

Plants could be regarded as small chemical factories, which produce chemical substances via photosynthesis. If we can imitate photosynthesis in an artificial system, we can make clean fuels and materials out of sunlight and CO2. Huub de Groot is very close to designing a system of this kind.

The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Centre with University of Havana.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

With a MSc in LST you are well prepared for a wide range of career opportunities. Life Science research and business is one of the fastest growing economic activities worldwide.

How can we organise society so as to keep our planet habitable for us and for all other life forms around us? To answer this question, Leiden researchers collaborate across disciplines, from biology to data science, and from environmental economy to archaeology.

PhD defence