1,868 search results for “osmaanse risk” in the Public website
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Disease: Plaque Characterization, Computational Haemodynamic Simulation and Risk Stratification
PhD defence
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What sets extremists who use terrorist violence apart from those who do not?
This paper contributes on an increasing body of work on radicalisation. It specifically focuses on what distinguishes individuals whose behavioural radicalisation includes involvement in terrorist violence from those whose behavioural radicalisation does not.
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Secret Intelligence and Public Diplomacy in the Ukraine War
In this article, Thomas Maguire, Assistant Professor at the Institute of Security and Global Affairs, examines why states use intelligence to influence external audiences.
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Inspirational practices in cultural heritage management: fostering social responsibility
This catalogue is the result of the EU_CUL project (2018-2021), which explores the use of cultural heritage in Europe for fostering academic teaching and social responsibility in higher education.
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Microfoundations of Debt Crises (MIDEBT)
How do citizens think about government debt? This project investigates the political roots of government debt crises by exploring the drivers of citizens’ preferences towards fiscal policies.
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Fate, accumulation and impact of metallic nanomaterials in the terrestrial environment
The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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Mood variability during adolescent development and its relation to sleep and brain development
During adolescence, mood disorder onset peaks. Mood variability is associated with negative mental health outcomes, so understanding biological factors that might be associated with mood variability, such as sleep and structural brain development, could elucidate the mechanisms underlying mood and anxiety…
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Business Interests and the Development of the Modern Welfare State
This edited volume provides a synthesis on the question of business attitudes towards and its influence over the development of the modern welfare state. It gathers leading scholars in the field to offer both in-depth historical country case studies and comparative chapters that discuss contemporary…
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri
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Labor Divided in the Postwar European Welfare State. The Netherlands and the United Kingdom
This monograph, written by dr. Dennie Oude Nijhuis and published by Cambridge University Press, discusses the postwar development of the welfare state.
- Institute of Urban Environment
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Ultrasensitive in situ visualization of active glucocerebrosidase molecules
Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Self-regulation in boys with ODD/CD
Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Benefit for all – An ecosystem for a healthy lifestyle
The BENEFIT programme is a public-private ecosystem in a national consortium, aiming to support patients with cardiovascular diseases in their own home setting for a long-term healthy lifestyle.
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Science in the Media
How can we bridge the gap between experts and the general public?
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ACCESS DENIED! – Girls’ Equal Right to Education in a global context, with a focus on Pakistan
Which challenges exist for girls to effectuate their right to education and specifically getting access to education?
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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The social brain in adolescence
What is the neural basis of social decision-making across childhood, adolescence and adulthood and what are the developmental patterns in terms of behavior and brain activation?
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver
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Clinical Neurodevelopmental Sciences Leiden University
The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.
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House Rules
On this page you will find all the house rules and conditions that apply to visiting the Old Observatory.
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India’s First Diplomat: V.S. Srinivasa Sastri and the Making of Liberal Internationalism
V.S. Srinivasa Sastri was a celebrated Indian politician and diplomat in the early twentieth century. Despite being hailed as the ‘very voice of international conscience’, he is now a largely forgotten figure.
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Predictive value of semi-physiological models for clearance of renally excreted drugs across the paediatric age range
The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.
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PNEC-pro
PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel, and zinc based on biotic ligand models (BLMs).
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Freedom AND Security - Conference Report Published by Europol
On 22 November 2018, Els De Busser spoke at a panel during the conference
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Data science for tax administration
In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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Subjects Barbarian, Monstrous, and Wild: Encounters in the Arts and Contemporary Politics
Subjects Barbarian, Monstrous, and Wild responds to a contemporary political climate in which historically invested figures of otherness—barbarians, savages, monsters—have become common discursive currency.
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How partisan politics influence government policies in response to ageing populations
Kohei Suzuki is Assistant Professor at Institute of Public Administration. This study carries several important implications for understanding the policy impacts of a graying population and for studies of the welfare state, in general.
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Religion, Class, and the Postwar Development of the Dutch Welfare State
Religion, Class, and the Postwar Development of the Dutch Welfare State. Dennie Oude Nijhuis.
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Voila/Neuromet
To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.
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Conflict Management in the Mediterranean and the Atlantic, 1000-1800
Pre-modern long-distance trade was fraught with risks which often created conflicts of interest. The ensuing disputes and the ways the actors involved dealt with them belong to the field of conflict management.
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Research
Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.
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Liver X receptor: therapeutic targeting of common pathways in Psoriasis and Cardiovascular co-morbidities
Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).
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Nanodata – Data providing services in support of research and policy in the field of nanosciences and nanotechnologies
This project, commissioned by DG Research and Innovation, aims to provide information for policies that lead to the creation and improvement of the conditions which will allow researchers and European industries to safely master the properties of nanomaterials and to innovate with nanotechnology.
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The right to health of the child : an analytical exploration of the international normative framework
Large numbers of children all over the world face significant health risks, such as infectious and chronic diseases, malnutrition, injuries and the consequences of natural disasters, protracted armed conflicts and poverty.
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A bibliometric review of COVID-19 research in the crisis and disaster literature
In the wake of the COVID-19 pandemic, the pressing question is how this global health emergency impacted the research agendas of the field of crisis and disaster science. This article reviewed contributions in ten important crisis and disaster journals in the two and a half years following the COVID-19…
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Gemeente Leiden: Water and Climate Change. Climate Proofing Industrial Estates
Climate Proofing Industrial Estates: Entrepreneurs’s Participation in the City of Leiden
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Terrestrial field trials for side-effects of pesticides
The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…
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The prudent entrepreneurs: women and public sector innovation
Kohei Suzuki, assistant professor at Leiden University, together with Victor Lapuente, examined how male and female public managers show attitudinal differences toward innovation in the public sector.
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Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
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Gemeente Leiden: Water and Climate Change. Climate Proofing the Neighbourhood
Climate Proofing the Neighbourhood: Evaluating Citizen’s Participation in the City of Leiden