946 search results for “immuniteit infection en tolerance” in the Public website
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon
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Semi-partitioned Scheduling and Task Migration in Dataflow Networks
Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov
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Ecology and conservation of spotted hyena in human dominated landscapes in northern Ethiopia
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen), Co-promotor: H.H. de Iongh
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Key publications
Key publications of the Biologics Formulation group
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Amsterdam's Atlantic: Print Culture and the Making of Dutch Brazil
The rise and fall of Dutch Brazil (1624-1654) was a major news story in early modern Europe, and marked the emergence of a
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The unexpected norm-setters: Intelligence agencies in cyberspace
Ilina Georgieva published an article in the journal Contemporary Security Policy on the norm-setting role of intelligence agencies.
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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MicroSOS
The MicroSOS project is designed to bring together academic and industrial partners with different expertises to address challenges that agriculture is facing due to climate change and invests in the development of microbiome-based solutions towards more sustainable agricultural practices.
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Respiratory health and disease in the Netherlands
Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.
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Noortje Dannenberg
Science
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Researchers discover how malaria parasite survives in mosquitoes
Researchers from Leiden University Medical Center (LUMC) have discovered how malaria parasites escape the immune system of mosquitoes. The so-called QC enzyme changes proteins on the outside of the malaria parasite such that the immune cells are unable to recognise the parasite. As a result, the parasite…
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Workshop CV en brief
Career and apply for jobs
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development for vaccines and therapeutics against respiratory virus infections
PhD defence
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Galactofuranose biosynthesis in the filamentous fungus Aspergillus niger
This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.
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Development and evaluation of evidence based self-help and online programs for people with a somatic stressor and depressive symptoms
What is the effectiveness of (booklet or online) self-help programmes for people with somatic stressors and depressive symptoms? What works best for whom? How to improve motivation and adherence?
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Arabic and Aramaic in Iraq: Language and Syriac Christian Commitment to the Arab Nationalist Project (1920-1950)
Tijmen Baarda defended his PhD thesis on 8 January 2020
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The World and The Netherlands: A Global History from a Dutch Perspective
This book examines the history of The Netherlands in a way that connects global processes to local developments.
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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as
Source: Eur J Med Chem (2015)
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Studying in the Netherlands
Inspiring and relaxed – these are qualities that describe the Netherlands perfectly. At the same time, there is much more to say about the country. For instance, according to the 2018 UN Human Development Index, the Netherlands is ranked tenth among the best countries to live in.
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The International Civil Service: Redefining Its Independence
On 18 April, Alexandre Tavadian defended the thesis 'The International Civil Service: Redefining Its Independence'. The doctoral research was supervised by Niels Blokker and Brian McGarry.
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Continuing your studies
If you want to continue your academic education, the logical next step after obtaining your bachelor’s degree is to follow a master’s programme. You can do so at Leiden University, or at another university in the Netherlands or abroad.
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Current and next generation influenza vaccines: Formulation and production strategies
Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…
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Chemical biology of antigen presentation by MHC molecules
MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.
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Non-target effects of GM potato: an eco-metabolomics approach
Promotors: Prof.dr. P.G.L. Klinkhamer, Prof.dr. P.M. Brakefield
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Synthetic biology and genomics platform for new-to-nature bioactive peptides
Can the venom of snakes, scorpions and other animals be sources of new antibiotics?
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Synthesis of phosphodiester-containing bacterial cell wall components: teichoic acids, capsular polysaccharides and phosphatidyl glycerol analogues
Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Semisynthetic glycopeptide antibiotics
Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.
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Comparative biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Targeted biomolecule production for therapeutic use
We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Fast vaccine design and development based on correlates of protection (COPs) Influenza as a trendsetter
New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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Do fungi differ? Understanding the mechanisms of mycorrhizal fungal impacts on soil C sequestration
How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?
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Amphiphilic miktoarm star copolymers
Within this project, PeptoMiktoStars were realized through an orthogonal protecting group strategy and should be investigated further regarding their potential as drug delivery systems in the field of drug delivery to inflamed areas in cancer, bacterial infections or autoimmune diseases.
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Using cryo-EM methods to uncover structure and function of bacteriophages
Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Institute for Chemical Immunology
Overkleeft
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Improved storage stability and immunogenicity of hepatitis B vaccine after spray-freeze drying in presence of sugars
The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.
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Drugs with fewer side effects through a collaboration between LACDR and PTS
LACDR, the Leiden Institute for Drug Research, developed better tolerated excipients to prevent adverse effects related to the surface of nanosized drugs such as vaccines. LADCR professor of Biopharmacy Matthias Barz and Polypeptide Therapeutic Solutions (PTS) are collaborating to develop processes…
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Renewable Energy
The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.
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The developing brain and behaviour
The more opportunities a child has to learn and develop, the stronger his or her future position in society. Leiden University investigates how the brain picks up information, and how learning processes can be influenced positively.
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Governance and society
Governance is a complex puzzle of organisations, people and divergent interests. Academic research in this field furthers our knowledge of the role of public administrators, of different organisational structures, of the people who work at such organisations and of how these organisations implement…
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A fitting punishment
A punishment that fits the crime is the cornerstone of the rechtsstaat or constitutional state. But opinions differ greatly on what constitutes a just and effective punishment. Research by Leiden University provides politicians, legislators, law enforcers and the public with new information and insights…