Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Supervisor: P.J.J. Hooykaas

Can new variants of daptomycin and the polymyxins be found?

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

Promotor: G.P. van Wezel

The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

Political scientists Huib Pellikaan and Niels van Willigen (Leiden University) use and elaborate on the theoretical insights from game theory in order to understand nuclear security in changing environment. Now that the relations between the US and Russia have deteriorated and smaller nuclear states…

In ‘Dimensions of Free Speech’, Devrim Kabasakal Badamchi (Leiden University Institute of Political Science) offers a new theoretical framework for free speech by critically analysing the major justifications for free speech. Kabasakal Badamchi argues for a justification: namely the double-grounded…

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Bringing the theoretical world of mathematics and computer science to more applied research areas. That is what Daan Pelt, assistant professor at the Leiden Institute of Advanced Computer Science (LIACS) is trying to achieve with the methods he is developing as a solution to challenges in image proc…

Everyone has heard arguments like this before as a child: ‘Whether you like it or not, you have to go to school!’ It seems as though you are presented with two options, but there is only one real outcome. Charlotte van der Voort of the MA Dutch Studies won the Leiden University Thesis Prize on her research…

“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

In this thesis,

The Encyclopedia of Global Human Migration provides a complete exploration of the prominent themes, events, and theoretical underpinnings of the movements of human populations from prehistory to the present day.

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

Evolution & Biodiversity is one of the four research themes of the Institute of Biology Leiden.

PhD defence

PhD defence

PhD defence

Promotor: B. van de Water

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

How does FoxP1 affect auditory perception on a behavioural and genomic level?

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Promotor: Prof.dr. J. Memelink

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Promotor: A. Doelman, Co-promotor: M.F.E. de Jeu

Promotor: Robert Tijdeman, Co-promotor: Cornelis Kraaikamp

The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.

JUSTREMIT and the Institute of Security and Global Affairs at Leiden University will host a conference on 12 and 13 October on Global Regulatory Regimes and Remittances. invite paper and panel proposals for consideration for the third JUSTREMIT Conference. Academics, practitioners from the regulatory…

The 18th-century rediscovery of the three archaic Greek-Doric temples in Paestum in southern Italy turned existing ideas on classical architecture upside down...

This subproject of 'From Homo Economicus to Political Animal' analyzes Greek economic thinking of the Hellenistic period.

Promotor: S.M. Verduyn Lunel, Co-Promotor: O.W. van Gaans

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.