420 search results for “gene” in the Public website
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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Using zebrafish to target the Achilles’ heel of cancer
Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.
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Awards and Grants 2022
An overview of awards and prizes granted to our staff and students in 2022, as well as special appointments at Leiden University and other institutions.
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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United States
This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with Boston Children’s Hospital in the USA.
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Research lines
Physics and Engineering Approaches to Biomedicine and Pharmacology
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Physics and Engineering Approaches to Biomedicine and Pharmacology
Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.
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Formulation and Characterization of Vaccines
Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…
- About this minor
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Statistics & Data Science (MSc)
The master’s programme Statistics & Data Science provides students with a thorough introduction to the general philosophy and methodology of statistical modelling and data analysis. The programme has two specialisations: Data Science and Statistical Science.
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Vision and Mission
The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.
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Cancer Therapeutics and Drug Safety
In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…
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Image-based Computational Biology
In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…
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Theory
Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…
- Research Dossiers
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Veni awards for seventeen young Leiden researches
The Netherlands Organisation for Scientific Research (NWO) has awarded Veni funding to seventeen researchers who recently obtained their PhD. This award offers promising young scientists the opportunity to develop their own ideas over a period of three years.
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ERC Consolidator Grants for Leiden researchers
Five Leiden researchers have been awarded a Consolidator Grant by the European Research Council (ERC). This grant of up to two million euros will enable them to continue and expand their scientific research.
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LUMC signs international agreement on developing Advanced Therapy Medicinal Products
Skåne University Hospital, Lund University and Leiden University Medical Center will work together to expand their research, teaching and development relating to Advanced Therapy Medicinal Products. That is the essence of a Memorandum of Understanding signed at SciLifeLab near Stockholm on Wednesday…
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New cell therapy facility at Leiden Bio Science Park
American pharmaceutical company Bristol Myers Squibb will be building a new (CAR-T) cell therapy facility in the Oegstgeest part of the Leiden Bio Science Park. The company will manufacture and develop CAR T-cell therapy for patients with blood cancer (leukaemia), for example.
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Matching medication to DNA leads to 30% fewer side effects
According to the LUMC, patients experience 30% fewer serious side effects when medication doses are tailored to their DNA.
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First clinical trial with genetically modified malaria vaccine completed
In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.
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New insights for improved pertussis vaccines - Press release -
Researchers in Bilthoven, The Netherlands, have recently unraveled the defense against whooping cough bacteria in unprecedented detail. The outcome of the project, conducted at Intravacc (Institute for Translational Vaccinology) in Bilthoven, provides opportunities for a new approach in the development…
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King of Sweden visits Leiden University
Collaborating in drug discovery and health research was the goal of a visit to the Leiden Bio Science Park on 14 May by a Swedish delegation including His Majesty King Carl XVI Gustav of Sweden. The delegation visited Leiden University’s Faculty of Science.
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Snake genomes revealed for King Cobra and Burmese Python
Freek Vonk and Mike Richardson, with many collaborators, have published two snake genomes in two parallel articles in the prestigious journal PNAS. Their new findings provide insight into the co-evolutionary arms race between predator and prey.
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MOU Signing Between Leiden University And ACTA
A Memorandum of Understanding was signed by Professor Corinne Hofman of the Faculty of Archaeology, Leiden University and Professor Albert Feilzer from the Academic Centre for Dentistry (ACTA), University of Amsterdam and VU University, Amsterdam.
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NWO Projectruimte Grant for DNA Flexibility Research
Theoretical physicist Helmut Schiessel receives an NWO Projectruimte grant of 390,000 euro. He will use this budget to hire a postdoc and a PhD student to continue his research on flexibility of double stranded DNA.
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DNA dating at Lowlands
Why do opposites attract? According to Karin van der Tuin, researcher at Leiden University Medical Center (LUMC), it could be because of your DNA. The more you differ from one another, the better. She will be testing her ideas at the Lowlands festival Lowlands, where she will subject visitors to DNA…
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Auxin
Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Want to do scientific research at Lowlands?
The Lowlands pop festival is inviting scientists to make proposals for research at this year's festival (19 to 21 August).
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New book by Wim Voermans on Dutch political & governance culture: past and present
The past decade, against the backdrop of a fragmented political landscape, has witnessed the greatest changes to the Netherlands since the aftermath of the Second World War. The labour market, the housing market, the energy market, the bank system, the pension system, the healthcare system, to name…
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Open Day Success
The Open Day of Leiden University, on the 8th of this month, was a success again: 483 prospective students came to find out what Leiden has to offer. The Institute of Biology Leiden was also present.
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Vici grants for three Leiden researchers
Three Leiden researchers have been awarded a prestigious Vici grant, the Dutch Research Council (NWO) announced on Tuesday. Two of the researchers work at Leiden University and the third at the Leiden University Medical Center (LUMC).
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Staying healthy with big data
By analysing the metabolism using big data techniques, we can identify health risks at an earlier stage. Thomas Hankemeier, professor of Analytical Biosciences at the Leiden Academic Centre for Drug Research, explains how that works.
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Mathematics, medicine and teaching
Mathematician Stéphanie van der Pas, winner of the C.J. Kok Jury Award for her PhD thesis in 2017, divides her time between research and education, and between pure mathematics and practical application.
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18 Veni subsidies for Leiden, 8 for our faculty!
This year, NWO has awarded a Veni subsidy to 143 young researchers who have recently obtained their PhD. 17 of these researchers are at Leiden University and one works at the LUMC. The successful applicants will each receive 250,000 euro to develop their ideas and carry out research over a period of…
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Success for Leiden with Vidi subsidies
NWO has awarded a Vidi subsidy to a total of 89 young and innovative researchers. Leiden researchers have won twelve of these subsidies and three subsidies have gone to the LUMC. Each researcher will receive up to 800,000 euro to develop a particular research theme or to set up a research group.
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Sex and gender analysis needs a more prominent role in research
Researchers, policymakers and funders have to take more account of the effect of sex and gender in scientific research. This is the view presented in an advice paper published by LERU, the League of European Research Universities. The lead author is Vice-Rector Simone Buitendijk.
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700,000 euros for the fight against aggressive breast cancer
To inhibit proteins that contribute to the growth of aggressive cancer cells, that’s the plan of Professor Bob van de Water and his team. They will receive over 700,000 euros from the KWF Dutch Cancer Society for their research. Researcher Maaike Vreeswijk and pathologist Danielle Cohen are affiliated…
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Leiden University involved in five Gravitation projects
Leiden University is involved in five new NWO Gravitation projects. Two relate to mental disorder and the remaining three to a healthy lifestyle, the combination of human and artificial intelligence, and the special relationship between plants and microbes.
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IBL symposium “Integrative Biology towards Healthy Communities”
On Monday the 8th of December, the annual symposium of the IBL will be organized at the main building of the LUMC Leiden. This year’s theme is “Integrative Biology towards Healthy Communities”.
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New STW-grant for study on crop protection
Dr. Kirsten Leiss and Prof. Peter Klinkhamer received 900.000 euro’s from “Stichting Toegepaste Wetenschappen (STW)” and the company “Rijk Zwaan” to develop plants that are resistant to thrips, a major agricultural pest all over the world.
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Dual appointment of seven new Medical Delta professors
Seven new Medical Delta professors revealed their research plans in a lecture marathon on 21 June. The professors at Leiden University, the LUMC, Delft University of Technology and the Erasmus Medical Centre Rotterdam operate at the interface between life sciences and health and technology.
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Remko Offringa appointed Professor in the field of Plant Developmental Genetics
Remko Offringa has been appointed Professor in the field of Plant Developmental Genetics within the Faculty of Science at the Institute of Biology Leiden (IBL) from the 1st of April 2017. Offringa’s research focuses on the role of the plant hormone auxin in controlling plant growth and development,…
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How insects conquered land
IBL-researchers revealed in a new study that insects are successful on land because their eggs became protected against desiccation. An extraembryonic membrane in the egg, the serosa, helped insects to make the transition from water to land.
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Joke Meijer on the Nobel Prize for the biological clock
This year's Nobel Prize for Medicine goes to the three American researchers who have unravelled the mechanism behind the biological clock. Joke Meijer, Professor of Neurophysiology and an expert in the field of the sleep-wake rhythm, explained in Dutch newspapers Trouw and NRC why this discovery is…
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Zebrafish models for disease and environmental stress
We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.
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Altering the appearance of macrophages to prevent atherosclerosis
It might be possible to prevent atherosclerosis by changing the appearance of macrophages, cells of the immune system that for example digest foreign substances. In her PhD dissertation, Baoyan Ren examined several ways to do so.
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Preventing or curing diseases with X-omics
In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…
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New insights into evolutionary loss of digits
Merijn de Bakker and colleagues of the IBL-research group of Prof. Mike Richardson provide a unique view on digit evolution in crocodiles and birds in their recent study published in Nature.