The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

The master's programme in Chemistry offers you access to cutting-edge research. This research is concentrated in two areas: Chemical Biology and Energy & Sustainability. Students in the research area Chemical Biology will study fundamental biological and biomedical problems to understand physiological…

The Physics master’s programme offers you a research intensive and tailor-made study path on current topics in experimental and theoretical physics at an institute of international renown. We offer five research specialisations, with emphasis on either experimental or theoretical physics, which train…

The master's programme in Chemistry offers you access to cutting-edge research. This research is concentrated in two areas: Chemical Biology and Energy & Sustainability. Students in the research area Chemical Biology will study fundamental biological and biomedical problems to understand physiological…

The Physics master’s programme offers you a research intensive and tailor-made study path on current topics in experimental and theoretical physics at an institute of international renown. We offer five research specialisations, with emphasis on either experimental or theoretical physics, which train…

The MSc program Evolutionary Biology focuses on important factors for the evolution of organisms. It prepares you for a research careers at universities, research institutes, or biotechnology sector. It’s also possible to combine training in biological research with training in communication, education…

We bring science to your home! Join our online study called Biological Motion study!

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Animal Sciences’ contributions to the Evolution & Biodiversity research theme include evo-devo research, the evolution of cognitive and behavioural traits, and the evolutionary mechanisms of stress adaptation. This research involves both indoor and outdoor studies.

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

A comprehensive analysis of Nietzsche's conception of conflict and the way in which relations of struggle condition the organisation of complex systems (with a specific focus on the human psyche and the body politic).

Research at the BPOC/SSNMR group is comprised of the following research themes:

A network combining 9 academic research groups and 4 collaborating industrial companies will train the next generation of PhD students and post-doctoral researchers, in developing and applying novel experimental and theoretical methods in the NMR spectroscopy of systems containing paramagnetic metals.…

Leiden has a strong tradition in theoretical physics, thoroughly linked with experimental disciplines.

Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…

In Microbial Sciences, we perform multidisciplinary research to understand the structure and function of microbes at all levels of biological organization, from small molecules and cellular structures at atomic resolution to multicellular communities.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

In Europe, archaeological traces of fire become more frequent between 300,000 and 400,000 years ago; but could the earliest occupants have survived without fire for at least half a million years before this? How could the early occupants of Europe have kept warm and processed meat without fire?

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Enabling volume-restricted metabolomics using next-generation microscale analytical tools.

The research that is united in the Liveable Planet programme, touches upon a wide range of aspects of human life. The goal is to deepen and expand the scope and to connect more researchers. The following case studies are examples of current research projects.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Our scientists working with laboratory animals undergo training on animal experiments. In this training, researchers learn how to handle laboratory animals responsibly. Read more about the requirements we set for researchers working with laboratory animals.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Is it possible to synthesize industrially relevant compounds in a sustainable manner through the use of light-capturing cyanobacteria?

How did toxin genes evolve from harmless physiological genes?

TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…

This thesis presents the systematics, epidermal defense, and bioprospecting of wild orchids.

Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

How and why latex bearing plants select specific chemical compounds for eco-chemical interactions with its biotic factors?

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

The Altai region has yielded a cluster of Middle and Upper Paleolithic stratified sites that have been recently excavated using a multidisciplinary approach.

How does invasive hybridization affect threatened native species?

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?

All research at Leiden University is organised into institutes. To do justice to the wide spectrum of research (and consequently teaching) that comes from these, you will find descriptions of all the Leiden institutes on these pages.