Source: Mediators Inflamm (2014)

Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.

On the 4th of June, Menghui Shi successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Menghui Shi on this achievement!

In what ways can visual art play a vital role in countering the discriminating stigma experienced by transgender communities?

Promotor: Prof.dr. R.M.H. Merks

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Drawing on insights from past and contemporary scholars and world leaders, the report explores the concepts of a new social contract, a new global deal, and networked and inclusive multilateralism introduced recently by Secretary-General António Guterres to help the United Nations better grapple with…

In this article, Samir Negash, PhD candidate at the Institute of Public Administratation, discusses the discrepancy in European countries between the measured impact of immigration on the welfare state and how this impact is perceived by citizens.

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

In this project we develop algorithms to automatically detect a particular type of archaeological sites in satellite images of the Alps.

Which features characterize speakers’ voices, and how are these features determined by what a speaker is saying?

How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?

Animal Sciences’ contributions to the Evolution & Biodiversity research theme include evo-devo research, the evolution of cognitive and behavioural traits, and the evolutionary mechanisms of stress adaptation. This research involves both indoor and outdoor studies.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Grants awarded to molecular physiology research

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

Is it possible for sugar patterns on cells to activate the immune system to combat cancer?

This dissertation provides an account of polar questions in Italian dialects from a typological, theoretical and empirical perspective.

Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.

The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

Social relationships of students are important. Especially for students with problem behavior. How can a teacher support students in their social relationships via their own interactions with students? A lot, as is shown by a meta-analyses of Hinke Endedijk. She assessed almost 300 studies about teacher-student…

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

This dissertation examines what network in the human brain is involved in the perception of prosody and whether activity within this network is modulated by the personality trait alexithymia.

Matthew Hoye argues for a regulatory analytical perspective to look at the sanctioning of Afghanistan.

This article assesses Russian rhetoric toward Ukraine from 2004 to 2019 by analyzing statements by the Russian Ministry of Foreign Affairs.

Examining mediation and moderation.

Promotor: P.M. Brakefield

This project is aimed at 1) elucidating the role of attention in itch and pain, including orientation, and attentional disengagement (i.e., directing attention away) from itch and pain; and 2) modifiability of these attentional processes.

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A novel in vivo model system for studies on glucocorticoid resistance

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

The daisy has been crowned the Netherlands’ national flower. Rogier van Vugt, Head of Horticulture at the Hortus botanicus, explains why the daisy merits its elevation to national symbol.

Book historian Erik Kwakkel found an intriguing snippet of text earlier this week, that bears unexpected evidence of some of the problems encoutered by early printers: censorship and the affiliated fuss of seeking and printing Church approval.

Environmental researcher Paul Behrens generated both international as national media attention with his recent publication in Nature Energy. The media included Science Daily, Quartz and the Dutch financial newspaper Financieel Dagblad. In his publication, Behrens warns for possible power disruptions…

Jasmina Mačkić, assistant professor at the Europa Institute, presented her research during ‘The Dissident’, a live talk show which is organised regularly by World-Talks, on 24th May 2018. The event revolved around the Nigerian human rights defender Justus Ijeoma, the founder of the International Human…

The Risk and Regulation Lab from organises events and workshops in Leiden and The Hague. On this page you can read reports of the events that already took place.

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

In this project, we plan to combine two strands of research in speech processing: (a) the impact of prosody on speech processing and (b) the impact of musical training on speech processing. In our project we will test 8 year-old children with different degrees of musical training: (a) primary school…

How do dissociative states affect the ability to suppress emotional distraction (in the context of a working memory task) in patients with Borderline Personality Disorder?

What happens to electrical waves that have to cross gaps in insulation material around nerves in the human body

Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.

The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’