This book is about what happens when two people meet. Its main aim is to present an account of intersubjectivity.

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…

PhD defence

Inaugural lecture

On 16 December 2021, Lisanne van Houten defended the thesis 'Flexing the Slot Regime'. The doctoral research was supervised by Prof. P. Mendes de Leon and Prof. L. Pierallini (Luiss University Of Rome).

On 17 December 2018, Dejian Kong defended his thesis 'Civil Liability for Damage caused by Global Navigation Satellite System'. The doctoral research was supervised by Prof. dr. P.M.J. Mendes de Leon.

As Lila Abu Lughod pointed out in 1989, North Africa has been one of the geographical ‘zones of prestige’ for the development of canonical approaches and crucial theoretical debates regarding the comparative study of Islam.

On Thursday 16 November 2017 Thomas Leclerc defended his PhD Dissertation ‘A Corrective Approach to Reduce Aircraft Greenhouse Gas Emissions. Contribution to the Study of Interactions between Legal Orders of International Law’. The Supervisors are Professor P. Mendes de Leon and Professor L. Grard.

On 14 November 2019, Luis Fiallos Pazmino defended his thesis 'Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems'. The doctoral research was supervised by Prof. P.M.J. Mendes de Leon and Prof. E.C.P.D.C. De Brabandere.

On 18 June 2019, Neta Palkovitz Menashy defended her thesis 'Regulating a Revolution: Small Satellites and the Law of Outer Space'. The doctoral research was supervised by Prof. dr. P.M.J. Mendes de Leon and Prof. dr. G. Molier.

Southeast Asia is a term to denote a collection of at present eleven nation-states with an enormous diversity in languages, cultures and religions. Muslims can both take a majority and a minority position.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

The symposium is open to all registered participants and consists of a two-day programme and a poster session.

Research at the MCBIM group is comprised of the following research themes:

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

How does the photoregulation mechanism work in detail?

Two Cleveringa books from Theo ten Kate's law library were donated to Leiden University by grandson Sebastiaan ten Kate on 24 November. They are the dissertations of W. Hugenholtz and J.G.L Röder, both PhD students of Rudolph Cleveringa. Ten Kate: 'The University is the right place for the books. Here,…

It is time for the international community to put a stop to war crimes – especially against medical personnel, argued international chair of Doctors Without Borders Joanne Liu in her Cleveringa lecture.

In recent years, and especially since the ‘Arab Spring’ of 2011, a growing body of research, media reporting, and scholarly literature has focused on the role of ‘Arab youth’ as the drivers of social and political movements across the Middle East and North Africa.

Critical Perspectives on Western Agency and Eastern Re-appropriations

LUCIS is an interfaculty knowledge centre offering a multidisciplinary and comparative view on Islam and Muslim societies.

On 18 September 2019, Huw Llewellyn defended his thesis 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. The doctoral research was supervised by Prof. N.M. Blokker and Prof. L.J. van den Herik.

Now and then we organise book launches to present the latest publications, both academic and popular, in our broad field.

Seminar programme

This programme adopts a new approach based on the paradoxical nature of these responses in early modern Italy: it draws on rhetorical discussions of lifelikeness and living presence, and it uses the anthropological theory of art as agency developed by Alfred Gell.

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).

Recently, the PhD thesis of Lolu Danso Eweje appeared entitled ’Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin’.

Since the horrific events of October 7, 2023, Leiden students have grappled with difficult questions about Israel, Gaza and Israel/Palestine conflict more generally. Drawing on her expertise in the history of the Jewish experience in the diaspora and beyond, Prof. dr. Sarah Cramsey has held multiple…

Key publications of the Cardiovascular Pharmacology group