How has early development in R. ocellatus been modified as a result of its parasitic embryonic lifestyle?

An overview of research themes and projects at ABS.

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

The Faculty of Medicine

The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.

Who were the main artists and producers who generated new forms of popular music? What was the music like that was produced by artists in particular urban settings? How were particular lifestyles articulated to identify new audiences and what does this reveal about the way popular music contributed…

We as Young Academy Leiden are continuously educating ourselves and are listening to the voices coming from our own university, especially voices of young academics. In order to amplify those voices, we have set up a new blog called ‘Voices of Young Academics’. It features contributions from early career…

The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.

The LUMC, Leiden University and The Hague University of Applied Sciences want to help health professionals support behaviour change in the population. Such change would help people live healthier lives and reduce their risk of disease. The Municipality of The Hague is supporting this educational project…

PhD defence

Free cinema tickets or a step tracker paid for by your health insurance. Some insurers offer rewards to promote healthy behaviour. But does the threat of losing something like a deposit work better? And what do patients think? This is what PhD candidate David de Buisonjé researched.

The Urban Studies bachelor’s programme is based on two learning trajectories. One is dedicated to knowledge related to urban issues, while the other focuses on a wide range of practical and academic skills.

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Depression has traditionally been linked to increased inflammation. Innovative research by psychologist Eiko Fried refutes this popular assumption. He shows that specific depression symptoms such as sleeping problems explain this relationship. Publication in Psychological Medicine .

PhD defence

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

Education & outreach

What is the role of stress and stress-related hormones in emotion regulation?

The research team

The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…

How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.

Our research at CWTS is organized in three focal areas. These focal areas represent our core areas of interest, as defined in our knowledge agenda for the period 2023-2028.

What are the social and neural mechanisms that contribute to fluctuations in self-esteem in healthy adolescents and adolescents with depression?

For knowledge to really benefit society as a whole, knowledge institutions, the municipality, citizens, and all other parties or organizations involved need to be aware of each other's contributions and needs. The Leiden Healthy Society Center has the ambition to connect up knowledge, policy, and practice…

Currently, Navigation Lab Leiden works on three main themes: navigation ability, spatial abilities, novel techniques in neuropsychology.

Focus in skin research

Promotor: S.M. Verduyn Lunel

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.

This article aims to contribute to the debate about citizen involvement in medical and social issues by studying co-production initiatives in The Hague.

Promotor: B. van de Water

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

The effectiveness of the skin barrier underlies the outer layer of the skin: the stratum corneum (SC). However, in several skin diseases this barrier is impaired. In two inflammatory skin diseases, atopic eczema and Netherton syndrome, an increased level of monounsaturated fatty acids (MUFAs) has been…

I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.

Living labs make it possible for citizens to participate in research for sustainable development of their environment. This way citizens, together with scientists and stakeholders, create local conditions for food production, healthy environment, and biodiversity.

Can we link multiple components from herbal extracts with their biological activities?

The University’s Vision on Student Well-Being outlines how the University plans to promote student well-being in the coming years.

Medical technology has become an essential part of healthcare. Innovative treatment methods therefore require a new type of medical professional. Someone with medical and technical knowledge, who builds a bridge between technology and patient.

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Stimulating the vagus nerve, which provides a direct link between the gut and brain, makes people pay less attention to sad facial expressions. This research study by psychologists Katerina Johnson and Laura Steenbergen is published in the journal Neuroscience, and made it to the cover.

Promotor: J. A. Bouwstra

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Developmental and Educational psychology is concerned with the developmental course and dynamics of cognition, self-regulation, and emotional competence, and the implications for educational and clinical practice.

If you wish to know exactly what is going on in a healthy or sick human body, and at various levels such as molecule, cell, tissue, organ, larger systems and a person as a whole? Do you wish to learn how to do research which contributes to diagnoses, treatment and prevention of diseases? Then the bachelor…