Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.

How can zebrafish research help to understand and fight human cancer?

The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

This dissertation provides crucial but as yet missing empirical data on the tone accent opposition in the so-called

‘What I find most alluring about soil life is that you can steer it,’ researcher Martijn Bezemer of the Institute Biology Leiden (IBL) reveals. ‘You can ask: What do you want? And then I can transform the soil into something you need. At least, that is what we thought.’

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Every summer, Leiden University is the setting of dozens of summer schools in which professionals and students can receive extra training on a specific topic within a short space of time. We took a look at a summer programme on extremism. ‘A recruiter for al-Qaeda said that I could change the world.…

Identification and characterization of components of DNA repair pathways and their role in Agrobacterium T-DNA integration and repair of CRISPR/Cas induced DSBs.

Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.

Promotor: S.J. Edixhoven

On Thursday 23 November, Professor Betty de Hart delivered the lecture ‘Exploring the Legal Archive on Race: Methodological Challenges’ as part of the lecture series ‘Reconsidering the Socio-Legal Gaze’ organized by the Van Vollenhoven Institute. Over 40 people attended the lecture, held online due…

PhD defence

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

How do macrophages and neutrophils contribute to metastatic onset?

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Promotor: J.M. Memelink

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Promotor: P. Stevenhagen, Co-promotor: R.M. van Luijk

Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

Using mathematics to determine whether scientific results are significant or not. Peter Grünwald, full professor of Statistical Learning at the Mathematical Institute (MI) and senior researcher in the Machine Learning group of Centrum Wiskunde & Informatica (CWI), has been awarded an ERC Advanced Grant…

Promotor: Prof.dr. A. Achucarro, Co-Promotor: J.W. van Holten

Jelle van Buuren, Assistant Professor at the Institute of Security and Global Affairs, appeared as guest on VICE to discuss the usefulness of recent ban on QAnon.

Jelle van Buuren, Assistant Professor at the Institute of Security and Global Affairs at Leiden University, can be heard in the latest Podcast of Wetenschap.nu.

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

PhD defence

How can zebrafish research help understanding human diseases?

By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

During the final meeting of the Thesis Project on 10 February at 'Pand Zuidwest' in The Hague, several students presented their theses. Students from different disciplines conduct research on formulated practice-oriented challenges in The Hague South-West. 'The Thesis Project provides a connection between…

Professor Edwin Bakker, director of the Centre for Terrorism & Counterterrorism, released his new book “Terrorism and Counterterrorism Studies: Comparing Theory and Practice”, published by Leiden University Press.

Dr Anouk Goemans has been appointed professor by special appointment of Youth Services and Child Protection from an Educational and Legal Perspective as of 1 November 2024. This chair is funded by the 'Stichting Steunfonds Pro Juventute' support fund foundation and serves as a bridge between the Department…

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

The most recent edition of the journal ‘The Theory and Practice of Legislation’ contains a contribution by Jelle But, Demy Jongkind and Wim Voermans.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.