Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Promotor: W. Jiskoot, Co-promotor: A. Hawe

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…

Prostate cancer (PCa) is one of the most prevalent cancer in males.

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Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Medical technology has become an essential part of healthcare. Innovative treatment methods therefore require a new type of medical professional. Someone with medical and technical knowledge, who builds a bridge between technology and patient.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

We are delighted to announce that Speech Prosody 2024 will be held in Leiden, The Netherlands (02–05 July 2024). The conference aims to showcase the facets of prosodic variation and their role in the production, comprehension, and acquisition of speech in order to obtain a better understanding of the…

Cognitive enhancement reflects the use of any (legitimate) means such as for example food supplements to reach one’s personal best.

Eduard Fosch-Villaronga, Marie Skłodowska-Curie Postdoctoral Researcher at eLaw- Center for Law and Digital Technologies, just published a book on Robots, Healthcare, and the Law. Regulating Automation in Personal Care.

To study relationships between emotion regulation after negative and traumatic life events and psychopathology. Within this context, another goal is to develop and validate emotion regulation questionnaires.

A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.

The Leiden University Medical Anthropology Network (LUMAN) brings medical anthropologists together with the aim of fostering interfaculty collaborations and creating common ground for working interdisciplinary on health-related themes in Leiden and beyond.

The major aim of the Health and Medical Psychology specialisation is to provide you with the theoretical background and professional skills required for health and medical psychology research and interventions. Health and Medical Psychology looks at how health, illness, and recovery are affected…

Art and science: are they polar opposites? The theme of this year’s Sculptures in Leiden open air exhibition is ‘life sciences’. It has resulted in many intriguing sculptures, including one that is especially endearing.

Professor of Health Psychology Andrea Evers is one of the coordinators of the national Health and Wellbeing programme and of the Leiden-Delft-Erasmus (LDE) programme that goes by the same name. The aim is to use technology to promote our health. LDE has already been working on this topic for some ti…

Student Marieke van der Heijden wandelt wekelijks met senioren bij het project Leren met de Stad. Zij doet onderzoek naar sociale cohesie in de wijk De Kooi.

By comparing individual health data with population data, doctors can provide personalized health advice and patients can learn from each other's experiences. Wessel Kraaij, professor of Applied Data Analytics shows how personal data can have predictive value.

Here, you can browse the publications of the Navigation Lab Leiden:

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

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PhD defence

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).

If a new method has been developed to recognize and treat a (neuro-)psychological disorder or related behavioral factors, it cannot yet be used directly in clinical practice. First, the method should be evaluated, preferably in randomized controlled trials.

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

Our everyday life consists of all sorts of spatial processes: we find our way to work, remember where we left our keys, and are able to pick up our cup of coffee. We study how the human brain processes such spatial processes. From a clinical perspective, we are interested in how acquired brain damage…

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

An important part of the SCS specialisation is the internship period. Students will get the opportunity to get to know the field and to apply what they have learned during the courses.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

The article 'Standardising care of the dying: An ethnographic analysis of the Liverpool Care Pathway in England and the Netherlands' by Erica Borgstrom and Natashe Lemos Dekker is published in Sociology of Health & Illness.

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence