Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

An overview of research themes and projects at ABS.

Are the types of school non-attendance which have been evidenced in typically developing youth also found among children and adolescents with an intellectual disability (ID)? If so, which types are most prevalent and thus in greatest need of attention, and what factors (child, family, school/environmental)…

Stephen Moore defended his thesis on 26 May 2020.

PhD defence

PhD defence

PhD defence

PhD defence

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

The Translational Immuno-Pharmacology group works on translating the efficacy of anti-infective therapy from preclinical (e.g. in vivo) to clinical, and is led by Rob van Wijk. Infectious diseases, such as tuberculosis, are in constant need of new therapies that work better, faster, and with less risk…

‘Raising awareness of the disorder is crucial since borderline personality disorder (BPD) still faces considerable stigma ’, says Anne Krause-Utz (Clinical Psychology) . Together with an international team of excellent scientists, Krause-Utz provides an update of current knowledge about this disorder,…

Female workers at Tesco Stores, a chain of supermarkets in the UK, brought a case to the European Court of Justice claiming they received unequal pay for doing work of equal value to that of their male colleagues.

A step-by-step approach to building confidence in anxiety-prone young children.

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

PhD defence

Leiden PhD candidate Mona Shahab climbed Mount Everest two years ago to raise money for the education of disadvantaged children in Egypt. She made it to the top and posed there with the University flag. She recently presented the flag to Rector Carel Stolker.

Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

A new therapy for the serious Graft-versus-Host disease

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

This dissertation attempts to describe the linguistic history of Hittite on the basis of a systematic etymological treatment of its entire inherited lexicon, precisely analyzing the phonological and morphological developments.

Can excessive worrying be reduced via stimulation of the vagus nerve?

Peer-mentored cognitive behavioral therapy for adolescents with mild intellectual disability and anxiety disorder

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

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Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

What are the circadian disturbances underlying depression vulnerability? How are they related to mood, cognition and sleep ?

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Chronic inflammatory skin diseases such as psoriasis and atopic dermatitis affect both the physical and psychological well-being of millions of patients, leading to persistent symptoms like itchiness and sleeplessness. These conditions often result in decreased productivity and quality of life overall,…

Michiel Claessen, Ineke van der Ham, Nicolien de Rooij and Anne Visser have published a paper in the Nederlands Tijdschrift voor revalidatiegeneeskunde, (Dutch Journal of Rehabilitation Medicine) entitled ‘De weg kwijt na een beroerte: screening, diagnostiek en behandeling’.

Leiden University will appoint Dr Anne-Laura van Harmelen as Professor of Brain, Security and Resilience at the Institute of Education and Child Studies with effect from 1 September 2020. She will focus on the brain in relation to the development of transgressive behaviour and its prevention and tre…

Seven talented female scientists join the fight against cancer of the Oncode Insitute. Laura Heitman of the Leiden Academic Centre for Drug Research is one of the new Junior Investigators. ‘I hope to discover new druggable targets’.

Sylvia van Beugen has won the Herman Musaph Literature award 2016 for the best publication about psychodermatology. Her publication describes the importance of body awareness in chronic skin conditions, such as psoriasis.

Stay tuned for updates on relevant media appearances of Anne-Laura van Harmelen.

This master specialization offers you a combination of theories about learning problems and impairments and intervention and prevention strategies from a developmental perspective.

Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Stressful events and a lack of support from the environment are both consequences and causes of mood swings in people with a bipolar disorder. This is the finding of PhD research by Leiden clinical psychologist Manja Koenders. PhD defence 7 April.