1,429 search results for “biomarkers discovery” in the Public website
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Societal impact
Research from the Living Lab is important for society. For example, scientists from the Living Lab discovered that the pesticide thiacloprid is up to 2,500 times more harmful to insects than was thought on the basis of regular lab research. Partly because of this discovery, the European Commission decided…
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Beyond the Site
The Saalian archaeological record at Maastricht-Belvédère (the Netherlands).
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
PhD defence
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Discovery of selective diacylglycerol lipase β inhibitors
PhD defence
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Discovery and characterization of new glucosylated metabolites
PhD defence
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Finding and valorizing new antibiotics using AI
Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…
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Pascal chair 2023
Peter Flach is Professor of Artificial Intelligence at the University of Bristol. An internationally leading scholar in the evaluation and improvement of machine learning models using ROC analysis and calibration, he has also published on mining highly structured data, on knowledge-driven and explainable…
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Programme structure
The Drug Discovery and Safety specialisation consists of compulsory and optional components.
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Tom van der Wel
Science
- Leiden Science in 2023
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Night of Discoveries with Leiden University researchers and fun activities
Festival
- Contact
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History
Life Sciences Artificial Intelligence Data Science
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Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
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Pursuing new anti-cancer therapy as a team
Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…
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Determining the kinetic profile of ENT1 inhibitors
Supervisor: Anna Vlachodimou
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Leiden Academic Centre for Drug Research
The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.
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Novel immunomodulatory drugs for tuberculosis treatment
Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?
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Teaching
At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.
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The Phantom of the Ego: Modernism and the Mimetic Unconscious
The Phantom of the Ego is the first comparative study that shows how the modernist account of the unconscious anticipates contemporary discoveries about the importance of mimesis in the formation of subjectivity.
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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The Complete Archaeology of Greece
This book covers the story of Greece and its central role in our understanding of European civilization, from the Palaeolithic era (400,000 BP) to the early modern period (1950 AD).
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Master's application and admission
Find out how to apply for Drug Discovery and Safety at Leiden University by following our step-by-step guide.
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Key publications
Key publications of the Computational Drug Discovery group
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Contact
Do you have questions about the Bio-Pharmaceutical Sciences master’s programme or the specialisation Drug Discovery and Safety? Please contact us.
- Discover the stem cell world during Night of the Discoveries!
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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Awards and Grants 2024
On this page you will find an overview of awards and prizes granted to our staff and students in 2024, as well as special appointments at Leiden University and other institutions.
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The History of the Arabic Script: New Discoveries and Developments
Lecture, Workshop
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Queen Máxima inspects zebrafish embryos
On Wednesday the 4th of September, Queen Máxima opened the renovated tropical greenhouse complex of the Leiden Hortus Botanicus. At the occasion Máxima met with IBL-PhD student Mahin Ghorbani from Iran and talked with her about her work on drug discovery from Iranian medicinal plants using zebrafish…
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Bio-organic Synthesis
The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…
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Chemical Probe Facility
The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…
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The Dakhleh Oasis Project
Update : March 2020 A.J. Mills
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Meet the professor in The Hague
Leiden University's professors will be going to elementary schools again to teach about science and research. During the class discovery-based learning will be central. The professors will go to several schools in The Hague. The classes are part of the university's celebration of its 445th birthday…
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Computational Network Science Lab
The Leiden Computational Network Science Lab (CNS Lab) researches methods for knowledge discovery from real-world network data.
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Formation of synthetic fuel: new insights!
Navarro Paredes
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Projects
The Young Academy Leiden and its workgroups have launched different initiatives in the interest of early-career scholars. Read all about the different projects of the Young Academy Leiden here.
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Applied String Theory: Explaining Quantum Matter with Black Holes
Schalm
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.