Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

The Leiden University-European Center for Chinese Medicine and Natural Compounds (LUECCM) is a virtual research Centre bringing together research projects of many different researchers from different origin.

Promotor: Prof.dr. M. Ubbink

Electron microscopy has become an extremely important techniquein a wide variety of elds.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.

Patterns of paleomobility in the Caribbean were studied through an inter-disciplinary approach using a combination of archaeological, osteological, mortuary, and isotopic data.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Can we link multiple components from herbal extracts with their biological activities?

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Completing your Master’s in Biology gives you an internationally recognised degree which you can follow up with a PhD track. With your acquainted skills, you’re a much requested professional in and outside research.

How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…

Leiden University offers you several services related to career orientation and job application skills.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

This is the physics summer school of Leiden University. It is part of the Leiden Institute of Physics (LION). The summer school is intended for Bachelor (BSc) students in physics. It covers topics from quantum matter and optics, to biological & soft matter physics and cosmology and theoretical physics.…

The programme offers you the ability to combine experimental research with theoretical courses. The programme helps you grow into an independent and skilled physicist.

The two-year Bioinformatics programme (120 EC) includes mandatory core courses and electives, as well as a Master's Thesis Research Project.

Bioarchaeology covers the study of all biological remains from archaeological sites.

How can species literacy in the Netherlands be explained and improved?

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

The Plant BioDynamics Lab (PBDL) is a laboratory dedicated to experiments designed to develop and validate quantitative mathematical models of dynamical processes in biology. The principal objective of developing these models is to make quantitative predictions about these processes.

The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

Can animal venoms yield novel antimicrobial peptides?

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

This is a joint PhD of the Faculty of Social and Behavioral Sciences at Leiden University and the Evolutionary Ecology Group at Antwerp University.

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.

In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…

Leiden University has a long tradition in the collaboration with Indonesia.

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.