Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Lecture

Lecture

This research evaluates the Youth Act. It will provide an overview of how the transition takes place, whether the transformation process develops in the right direction and whether the legal safeguards are functioning properly.

Lecture

Having a chronic somatic condition can result in a variety of impairments in patients’ daily lives, including not only physical complaints such as pain, itch, and fatigue, but also problems of negative mood and impairments in social relationships. Next to disease characteristics, individual difference…

PhD defence

Laura van der Plas has been Wellbeing Officer for the Campus Den Haag since the end of 2021. By means of various projects, she makes sure that more attention is given to student wellbeing. How are things going so far? And what are these projects exactly? Laura talked to us to give us an update.

In the Faculty of Archaeology depots, many artefacts, accumulated after decades of fieldwork across the world are stored. The Leiden Inventory of the Depot (LID) project aims to unlock the door to this wealth of information. Elizabeth Hicks, a Research Master’s student at the Faculty, will be re-evaluating…

Many biological processes occur by biomolecules coming together and organizing into specific clusters without being bound to each other. These interactions range from clustering, transiently interacting (kiss and run), or assembling to multimeric units that can only function in conjunction. The hydrogen…

Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

Within the Chinese medicine, more than 80% of the constituents of the preparations are derived from plants. Like any other organism, plants are constantly interacting with their changing and often harsh environment during the various phases of their life cycle.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies report on the detailed analysis of these classes in a single platform.

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

From nanoparticles to colliding ice planets and from biological origami to new x-ray scanner techniques: this year again, our scientists have made wonderful discoveries. From the largest numbers to the smallest molecules and from the oldest galaxies up to the latest algorithms, take a look at each institute's…

In the spirit of 'unity in diversity', our objective is to promote insight into and appreciation for the wonder that the same physical laws and mathematical concepts apply to the whole of nature, from the largest to the smallest energy and length scales. We strive for the application of abstract theoretical…

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Are you interested in the neurocognitive and biological roots of learning, behaviour and emotions in children? If so, the programme in Applied Neuroscience in Human Development might be the specialisation you are looking for.

Female and male songbirds sing equally elaborate songs in some species, but in others, females do not sing like males or not at all. How did such pronounced differences in male and female communication evolve?

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

The skin has recently gained attention within body studies for its many specific cultural and social associations, in addition to its biology. This project aims to examine the different layers of meaning and the functions invested in the skin in ancient Greece: how did ancient Greek literary and medical…

The MSc programme Physics offers 5 research-oriented specialisations where you can focus on Theoretical Physics, Quantum Matter and Optics, Biological and Soft Matter, or Cosmology. You can also combine Physics with education, management or science communication.

The research master's specialisation Clinical and Health Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.

Research within our group revolves around the atomic structures of large bio-molecules and their complexes.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.

Investigating domestic crafts and subsistence activities through experiments and material analysis

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

Three at the same time: a ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)-catalyzed click reaction was used to label the three catalytic activities of the proteasome simultaneously in a single experiment. The orthogonality of the three ligation…

The LUMC Flow Cytometry Core Facility accommodates all research and diagnostic flow cytometry equipment of the LUMC.

The explanation from physicist Scott Waitukaitis for the screaming and bouncing gel balls in a hot pan has been covered in several media, including the Washington Post.

On an apparently normal cube a pattern of hollows and bulges appears when the cube is compressed. A method has been developed to design such three-dimensional structures and to construct these using simple building blocks. Publication in Nature.

Manufacturers produce high-end technology mostly top-down with large machinery, but small particles are able to build structures by themselves from the bottom up. A major challenge is that these particles easily clump together. Leiden physicist Daniela Kraft has developed a method to use this phenomenon…

Young children, adolescents and students may experience learning difficulties as a result of lack of sleep. Dr Kristiaan van der Heijden investigates sleep problems and solutions for various age groups.

The Leiden Institute of Chemistry (LIC) offers a unique tailor-made programme in Chemistry. You can customize the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either Chemical Biology or Energy & Sustainability. During the Master's…

Conference, Seminar

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

We have recently discovered that there are biological proteins that phase separate out of solution much the way oil will de-mix from water (see movie). These form dense, liquid-like phases called protein condensates.

The Leiden Institute of Physics (LION) offers bachelor and master level education in physics at Leiden University.

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…