1,597 search results for “anti-cancer drug steen” in the Public website
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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Dynastischer Nachwuchs als Hoffnungsträger und Argument in der Frühen Neuzeit
This volume sheds light on the role played by progeny in maintaining dynasties in early modern royal courts as well as the horizontal and vertical interplay between the actors. It attempts to break through the narrative of older research that saw dynasties as a series of male rulers. Instead, these…
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Anthe Janssen
Science
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Joost Batenburg
Science
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Coen van Hasselt
Science
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Skin researcher calls for multidisciplinary collaboration: ‘I want to pool expertise’
In dermatology, there should be a high level of multidisciplinary collaboration among institutes and specialists, Professor of Translational Dermatology, Robert Rissmann, will say in his inaugural lecture on 8 July. He is building an infrastructure that will put pre-clinical and clinical skin research…
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How Oncode-PACT is bringing new cancer medicines closer with 325 million in Growth Fund money
How can you ensure that more experimental drugs reach the finish line? At the moment, only one in twenty cancer drugs that are tested on humans makes it to the market. This is an enormous loss for patients and society. With a grant from the National Growth Fund, Oncode-PACT aims to efficiently select…
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Text-mining real-world data to evaluate systemic anti-cancer therapy
PhD defence
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Is Michael Meijer the Smartest Chemist of the Netherlands?
He is occupied with the home stretch of his promotion. But in between, there is another challenge: Michael Meijer is going through to the finals of ‘The Smartest Chemist of the Netherlands’. On Tuesday 9 October, he and five others fight for this title during the Evening of Chemistry. ‘I was dragged…
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Different medication dosage for morbidly obese patients
PhD research recently completed by pharmacologist Margreke Brill shows that morbidly obese patients should be given a different dosage of the drugs Cefazolin and Midazolam. This could also apply to other drugs such as anti-cancer drugs as well as antibiotics and Margreke Brill is advocating a change…
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Molecular characterization of copper-dependent enzymes involved in Streptomyces morphology
Promotor: G.P. van Wezel, Co-promotor: D. Claessen
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Experiences with the Liverpool care pathway for the dying patient in nursing home residents
The Liverpool care pathway for the dying patient (LCP) is a multidisciplinary tool developed for the dying phase for use in palliative care settings. The literature reports divergent experiences with its application in a nursing home setting related to its implementation and staff competencies. The…
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Anton Pannekoek: Ways of Viewing Science and Society
Astronomer and Marxist Anton Pannekoek was a remarkable figure. This book aims to study the connections between his life as a socialist theorist and as a pioneering scientist through the prism of Pannekoek's biography.
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and Italian pharma company receive an EU grant to realise sustainable drug production
With a €1.5 million European grant, industrial ecologist Stefano Cucurachi will work on more sustainable production methods for the pharmaceutical industry. The Italian company Angelini Pharma intends to use the resulting knowledge to make its production process more sustainable.
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How to develop cancer drugs with less side effects
Lecture, Tuesday Talks: Science Insights
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Sebastian Pomplun
Science
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Characterization and skin permeation of ketoprofen-loaded vesicular systems
PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.
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De steen van Antoine de Saint-Exupéry - Bouwen aan de samenwerking tussen recht en gezondheid
Inaugural lecture
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Leiden PhD team in finals international pharmacological competition
A team of five PhD students from Leiden University is in the running for first prize in the Pharmacometrics Skills Competition. In a drug development simulation, they apply their mathematical pharmacological skills to solve clinical problems. On 24 March they will compete in the finals in Orlando, F…
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Is a cancer pill a matter of time?
A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.
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Screening enormous databases to find a cure for cancer
Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’
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UMCs join forces to increase pandemic preparedness
Four university medical centres, including the LUMC, are joining forces to increase pandemic preparedness in the Netherlands.
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Adam Cohen receives Dr. Saal van Zwanenberg Honorary Prize
Professor of Clinical Pharmacology Adam Cohen from Leiden University received the prestigious Dr. Saal van Zwanenberg Honorary Prize on 12 November. The prize honours a scientist who has distinguished themselves in the field of research that has directly or indirectly led to the development of new medicines…
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Who are the Squatters? Mapping and documenting squatting in Leiden as a cross-over project between Public History and Academic Research
This project sets out to map, document and analyze instances of squatting in Leiden from 1970 to 1990, in order to set up an online Digital Archive of Squatting in Leiden. This archive will function as an online resource for academic research, as well as a starting point for public activities such as…
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
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‘Take medicine target saturation into account’
Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…
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From discovery to business: 'In the lab, we often don't realise that we are working to help an immense number of patients'
'It gave our team a big boost to hear that our work was valuable,' says medical chemist Elmer Maurits about the moment they won the Venture Challenge. With their company Iprotics, they want to develop a drug that can better treat patients with autoimmune diseases and blood cancers. 25,000 euros of prize…
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New cellular imaging paves way for cancer treatment
A new technique using fluorescent imaging to track the actions of enzymes might aid drug design for new anti-cancer, inflammation and kidney disease treatments. Researchers at the University of York and Leiden University have published these findings in Nature Chemical Biology.
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A systematic review of current cybersecurity training methods
This article presents a systematic review aiming to provide a comprehensive overview of cybersecurity training methods and assess their effectiveness.
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Engagement of citizens and public professionals in the co-production of public services
The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…
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Beschadigd vertrouwen
On 7 December 2021, Georgina Kuipers defended the thesis 'Beschadigd vertrouwen'. The doctoral research was supervised by Prof. W. den Ouden and Prof. M.A. van der Steen (EUR).
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The dynamics of co-production at the street-level
How citizens and professionals are the key to successful collaboration in the delivery of public services. How do individual characteristics of citizens and professionals influence citizen-professional collaboration in the co-production of public services?
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Effectiveness of audience segmentation in instructional risk communication: A systematic literature review
This article provides a list of the concepts and key elements that should be considered when creating effective communication messages.
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Strategic Partnerships/ Cooperation Partnerships
Erasmus+ Strategic Partnerships (Key Action 2) are transnational projects designed to develop and share innovative practices and promote cooperation, peer learning, and exchanges of experiences in the fields of education, training, and youth. There are two kinds of Strategic Partnership; those supporting…
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Public leaders’ organizational learning orientations in the wake of a crisis and the role of public service motivation
This study explores public leaders’ organizational learning orientation in the wake of a crisis. More precisely, we study the association between public leaders’ public service motivation and their learning orientation (instrumental versus political).